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  • 1
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    Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-09-23
    Description: Calorie restriction extends life-span in a wide variety of organisms. Although it has been suggested that calorie restriction may work by reducing the levels of reactive oxygen species produced during respiration, the mechanism by which this regimen slows aging is uncertain. Here, we mimicked calorie restriction in yeast by physiological or genetic means and showed a substantial extension in life-span. This extension was not observed in strains mutant for SIR2 (which encodes the silencing protein Sir2p) or NPT1 (a gene in a pathway in the synthesis of NAD, the oxidized form of nicotinamide adenine dinucleotide). These findings suggest that the increased longevity induced by calorie restriction requires the activation of Sir2p by NAD.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lin, S J -- Defossez, P A -- Guarente, L -- 5-F32-AG05857-02/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 2000 Sep 22;289(5487):2126-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11000115" target="_blank"〉PubMed〈/a〉
    Keywords: Cyclic AMP-Dependent Protein Kinases/metabolism ; DNA, Circular/genetics/metabolism ; DNA, Fungal/genetics/metabolism ; DNA, Ribosomal/genetics/metabolism ; *Energy Intake ; Enzyme Activation ; *Gene Silencing ; Glucose/*metabolism ; Histone Deacetylases/genetics/*metabolism ; *Longevity ; Mutation ; NAD/*metabolism ; Pentosyltransferases/genetics/metabolism ; Recombination, Genetic ; Saccharomyces cerevisiae/genetics/metabolism/*physiology ; *Silent Information Regulator Proteins, Saccharomyces cerevisiae ; Sirtuin 2 ; Sirtuins ; Trans-Activators/genetics/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    HST2 mediates SIR2-independent life-span extension by calorie restriction (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-07-30
    Description: Calorie restriction (CR) extends the life span of numerous species, from yeast to rodents. Yeast Sir2 is a nicotinamide adenine dinucleotide (NAD+-dependent histone deacetylase that has been proposed to mediate the effects of CR. However, this hypothesis has been challenged by the observation that CR can extend yeast life span in the absence of Sir2. Here, we show that Sir2-independent life-span extension is mediated by Hst2, a Sir2 homolog that promotes the stability of repetitive ribosomal DNA, the same mechanism by which Sir2 extends life span. These findings demonstrate that the maintenance of DNA stability is critical for yeast life-span extension by CR and suggest that, in higher organisms, multiple members of the Sir2 family may regulate life span in response to diet.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lamming, Dudley W -- Latorre-Esteves, Magda -- Medvedik, Oliver -- Wong, Stacy N -- Tsang, Felicia A -- Wang, Chen -- Lin, Su-Ju -- Sinclair, David A -- R01 AG024351/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 2005 Sep 16;309(5742):1861-4. Epub 2005 Jul 28.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Paul F. Glenn Laboratories for the Biological Mechanisms of Aging, Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16051752" target="_blank"〉PubMed〈/a〉
    Keywords: *Caloric Restriction ; DNA, Fungal/genetics ; DNA, Ribosomal/genetics ; Gene Deletion ; Gene Silencing ; Genes, Fungal ; Histone Deacetylases/genetics/physiology ; *Longevity ; Mutation ; Niacinamide/pharmacology ; Recombination, Genetic ; Saccharomyces cerevisiae/genetics/*physiology ; Saccharomyces cerevisiae Proteins/*genetics/*physiology ; Silent Information Regulator Proteins, Saccharomyces cerevisiae/physiology ; Sirtuin 2 ; Sirtuins/*genetics/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
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    PAPER CURRENT
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