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  • Organic Chemistry  (3)
  • *Long-Term Potentiation/drug effects  (1)
  • 1900-1913  (1)
  • 1
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    Beiträge zur Frage Frosthärte der Getreidepflanzen (1913)
    In:  Ber. Deut. Bot. Gesell. 31: 507-513
    Details
    Publication Date: 1913
    Description: Zusammenhang zwischen Temperatur und Wachstum bei Getreide, Auswinterungshärte KATASTER-BESCHREIBUNG: KATASTER-DETAIL:
    Keywords: Deutschland ; 1900-1913 ; Getreide ; Frost
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    BIBLIOGRAPHY INKA BB
  • 2
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    Induction of synaptic long-term potentiation after opioid withdrawal (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-07-11
    Description: mu-Opioid receptor (MOR) agonists represent the gold standard for the treatment of severe pain but may paradoxically also enhance pain sensitivity, that is, lead to opioid-induced hyperalgesia (OIH). We show that abrupt withdrawal from MOR agonists induces long-term potentiation (LTP) at the first synapse in pain pathways. Induction of opioid withdrawal LTP requires postsynaptic activation of heterotrimeric guanine nucleotide-binding proteins and N-methyl-d-aspartate receptors and a rise of postsynaptic calcium concentrations. In contrast, the acute depression by opioids is induced presynaptically at these synapses. Withdrawal LTP can be prevented by tapered withdrawal and shares pharmacology and signal transduction pathways with OIH. These findings provide a previously unrecognized target to selectively combat pro-nociceptive effects of opioids without compromising opioid analgesia.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Drdla, Ruth -- Gassner, Matthias -- Gingl, Ewald -- Sandkuhler, Jurgen -- P 18129/Austrian Science Fund FWF/Austria -- New York, N.Y. -- Science. 2009 Jul 10;325(5937):207-10. doi: 10.1126/science.1171759.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurophysiology, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, 1090 Vienna, Austria.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19590003" target="_blank"〉PubMed〈/a〉
    Keywords: Analgesics, Opioid/administration & dosage/*adverse effects/pharmacology ; Animals ; Calcium/metabolism ; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-/administration & dosage/adverse ; effects/pharmacology ; Evoked Potentials ; GTP-Binding Proteins/metabolism ; Hyperalgesia/chemically induced ; *Long-Term Potentiation/drug effects ; Male ; Nerve Fibers, Unmyelinated/physiology ; Patch-Clamp Techniques ; Piperidines/administration & dosage/adverse effects/pharmacology ; Posterior Horn Cells/drug effects/physiology ; Rats ; Rats, Sprague-Dawley ; Receptors, N-Methyl-D-Aspartate/metabolism ; Receptors, Opioid, mu/*agonists ; Signal Transduction ; Substance Withdrawal Syndrome/*physiopathology ; Synapses/drug effects/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    PAPER CURRENT
  • 3
    Electronic Resource
    Electronic Resource
    Stabile protonierte PyrroleHerrn Prof. Dr. Karl Dimroth zum 70. Geburtstag gewidmet. (1981)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1981 (1981), S. 789-791 
    Details
    ISSN: 0170-2041
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Stable Protonated PyrrolesReaction of the di- and tri-tert-butylpyrroles4-7 with tetrafluoroboric acid yields the first protonated alkylpyrroles which can be stored for a long time without decomposition.
    Notes: Aus den Di- und Tri-tert-butylpyrrolen4-7 wurden mit Tetrafluoroborsäure die ersten nahezu unbegrenzt haltbaren protonierten Alkylpyrrole erhalten.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.198119810504
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  • 4
    Electronic Resource
    Electronic Resource
    Chemische Modifikation von Kanamycin A Derivate mit 4,5-Doppelbindung im Kanosamin-Teil (1985)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1985 (1985), S. 644-649 
    Details
    ISSN: 0170-2041
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Chemical Modification of Kanamycin A. - Derivatives Containing a 4,5-Double Bond in the Kanosamine PartOxidation of the primary alcohol group in the kanamycin A derivative 2b with simultaneous β-elimination gave the α,β-unsaturated aldehyde 3a of which the derivatives 3b - e were prepared by acetalisation, oxidation, or reduction. Hydrogenation of the double bond led to 4 ‚-deoxy-5‘-epi-kanamycin A derivatives.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.198519850327
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  • 5
    Electronic Resource
    Electronic Resource
    Reaktionen der D-Glucuronsäure, X. Eliminierungen an D-Glucofuranurono-6,3-lacton und seinen DerivatenHerrn Prof. Dr. L. Horner zum 65. Geburtstag gewidmet. (1977)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1977 (1977), S. 169-176 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Reactions of D-Glucuronic Acid, X.  -  Elimination Reactions of D-Glucofuranurono-6,3-lactone and its DerivativesIn the presence of bases D-glucofuranurono-6,3-lactone, its glycosides, and their 2,5-di-O-alkyl derivatives, respectively, form doubly unsaturated products. This reaction is initiated by proton abstraction at C-5 causing β-elimination with opening of the tetrahydrofuran ring and liberation of the aldehyde function. In a subsequent second elimination (2E, 4Z)-2,5-dihydroxy-and (2E, 4Z)-2,5-dialkoxy-6-oxo-2,4-hexadienoic acid, respectively, are formed, of which the former spontaneously isomerizes to the thermodynamically more stable (2Z, 4Z)-conformer.
    Notes: D-Glucofuranurono-6,3-lacton, seine Glykoside und deren 2,5-Di-O-alkylderivate reagieren mit Basen unter Bildung doppelt ungesättigter Produkte. Diese Reaktion wird durch Protonabstraktion an C-5 eingeleitet, wobei der Tetrahydrofuranring durch β-Eliminierung geöffnet und die Aldehydgruppe in Freiheit gesetzt wird. In der daran anschließenden Aldoleliminierung bilden sich (2E, 4Z)-2,5-Dihydroxy-oder (2E, 4Z)-2,5-Dialkoxy-6-oxo-2,4-hexadiensäure, von denen die erstere spontan zum thermodynamisch stabileren (2Z, 4Z)-Konformeren isomeriiert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.197719770117
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