Publication Date:
1988-09-16
Description:
A hybrid protein between interferon-gamma and tumor necrosis factor-beta was made by ligating the respective genes and expressing the fused genes under the control of the trp promoter in Escherichia coli. The antiproliferative activity of the hybrid protein in vitro was greatly increased compared with either interferon-gamma or tumor necrosis factor-beta alone, and both antiviral activity and cytotoxic effect were retained in the hybrid protein. The hybrid protein may have potential clinical application.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Feng, G S -- Gray, P W -- Shepard, H M -- Taylor, M W -- AI21898/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1988 Sep 16;241(4872):1501-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, Indiana University, Bloomington 47405.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3138754" target="_blank"〉PubMed〈/a〉
Keywords:
*Antiviral Agents
;
Cloning, Molecular
;
*Growth Inhibitors
;
Immunosorbent Techniques
;
*Interferon-gamma
;
Recombinant Fusion Proteins/pharmacology
;
Structure-Activity Relationship
;
*Tumor Necrosis Factor-alpha
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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