Publication Date:
1987-11-20
Description:
Immunotoxins are conjugates of cell-reactive antibodies and toxins or their subunits. In this report, the chemistry, biology, pharmacokinetics, and anti-tumor effects of first generation immunotoxins; the preparation of improved second generation immunotoxins that display greater anti-tumor efficacy; and the role of genetic engineering in creating third-generation immunotoxins are discussed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vitetta, E S -- Fulton, R J -- May, R D -- Till, M -- Uhr, J W -- CA-28149/CA/NCI NIH HHS/ -- CA-41081/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1987 Nov 20;238(4830):1098-104.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology, University of Texas Southwestern Medical Center, Dallas 75235.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3317828" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antineoplastic Agents
;
Clinical Trials as Topic
;
Humans
;
*Immunotoxins/pharmacokinetics/toxicity
;
Neoplasms, Experimental/therapy
;
Recombinant Proteins/therapeutic use
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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