Publikationsdatum:
2011-08-16
Beschreibung:
Infections localized to peripheral tissues such as the skin result in the priming of T-cell responses that act to control pathogens. Activated T cells undergo migrational imprinting within the draining lymph nodes, resulting in memory T cells that provide local and systemic protection. Combinations of migrating and resident memory T cells have been implicated in long-term peripheral immunity, especially at the surfaces that form pathogen entry points into the body. However, T-cell immunity consists of separate CD4(+) helper T cells and CD8(+) killer T cells, with distinct effector and memory programming requirements. Whether these subsets also differ in their ability to form a migrating pool involved in peripheral immunosurveillance or a separate resident population responsible for local infection control has not been explored. Here, using mice, we show key differences in the migration and tissue localization of memory CD4(+) and CD8(+) T cells following infection of the skin by herpes simplex virus. On resolution of infection, the skin contained two distinct virus-specific memory subsets; a slow-moving population of sequestered CD8(+) T cells that were resident in the epidermis and confined largely to the original site of infection, and a dynamic population of CD4(+) T cells that trafficked rapidly through the dermis as part of a wider recirculation pattern. Unique homing-molecule expression by recirculating CD4(+) T effector-memory cells mirrored their preferential skin-migratory capacity. Overall, these results identify a complexity in memory T-cell migration, illuminating previously unappreciated differences between the CD4(+) and CD8(+) subsets.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gebhardt, Thomas -- Whitney, Paul G -- Zaid, Ali -- Mackay, Laura K -- Brooks, Andrew G -- Heath, William R -- Carbone, Francis R -- Mueller, Scott N -- England -- Nature. 2011 Aug 14;477(7363):216-9. doi: 10.1038/nature10339.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology and Immunology, The University of Melbourne, Melbourne, Victoria 3010, Australia. gebhardt@unimelb.edu.au〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21841802" target="_blank"〉PubMed〈/a〉
Schlagwort(e):
Adoptive Transfer
;
Animals
;
CD4-Positive T-Lymphocytes/*cytology/immunology/metabolism
;
CD8-Positive T-Lymphocytes/*cytology/immunology/metabolism
;
*Cell Movement
;
E-Selectin/metabolism
;
Genomic Imprinting
;
Herpes Simplex/immunology/virology
;
*Immunologic Memory
;
Immunologic Surveillance/immunology
;
Ligands
;
Mice
;
P-Selectin/metabolism
;
Simplexvirus/immunology
;
Skin/cytology/immunology/virology
;
T-Lymphocytes, Helper-Inducer/cytology/immunology
Print ISSN:
0028-0836
Digitale ISSN:
1476-4687
Thema:
Biologie
,
Chemie und Pharmazie
,
Medizin
,
Allgemeine Naturwissenschaft
,
Physik
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