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  • 1
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    Complete genome sequence of the apicomplexan, Cryptosporidium parvum (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-03-27
    Description: The apicomplexan Cryptosporidium parvum is an intestinal parasite that affects healthy humans and animals, and causes an unrelenting infection in immunocompromised individuals such as AIDS patients. We report the complete genome sequence of C. parvum, type II isolate. Genome analysis identifies extremely streamlined metabolic pathways and a reliance on the host for nutrients. In contrast to Plasmodium and Toxoplasma, the parasite lacks an apicoplast and its genome, and possesses a degenerate mitochondrion that has lost its genome. Several novel classes of cell-surface and secreted proteins with a potential role in host interactions and pathogenesis were also detected. Elucidation of the core metabolism, including enzymes with high similarities to bacterial and plant counterparts, opens new avenues for drug development.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Abrahamsen, Mitchell S -- Templeton, Thomas J -- Enomoto, Shinichiro -- Abrahante, Juan E -- Zhu, Guan -- Lancto, Cheryl A -- Deng, Mingqi -- Liu, Chang -- Widmer, Giovanni -- Tzipori, Saul -- Buck, Gregory A -- Xu, Ping -- Bankier, Alan T -- Dear, Paul H -- Konfortov, Bernard A -- Spriggs, Helen F -- Iyer, Lakshminarayan -- Anantharaman, Vivek -- Aravind, L -- Kapur, Vivek -- U01 AI 46397/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2004 Apr 16;304(5669):441-5. Epub 2004 Mar 25.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Veterinary and Biomedical Science, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA. abe@umn.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15044751" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antiprotozoal Agents/pharmacology ; Carbohydrate Metabolism ; Cryptosporidium parvum/*genetics/*metabolism/pathogenicity/physiology ; DNA, Protozoan/genetics ; Drug Resistance/genetics ; Enzymes/genetics/*metabolism ; Ethanol/metabolism ; Genes, Protozoan ; *Genome, Protozoan ; Glycolysis ; Introns ; Mitochondria/genetics ; Molecular Sequence Data ; Multigene Family ; Open Reading Frames ; Organelles/genetics ; Protozoan Proteins/chemistry/genetics/*metabolism ; Purines/metabolism ; Sequence Analysis, DNA ; Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
    Electronic Resource
    Electronic Resource
    Inhibition by 1α, 25-dihydroxyvitamin D"3 of dimethyl sulfoxide-induced differentiation of friend erythroleukemia cells
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 119 (1984), S. 807-813 
    Details
    ISSN: 0006-291X
    Keywords: [abr] 1α(OH)D"3; 1α-hydroxyvitamin D"3 ; [abr] 1α,25(OH)"2D"3; 1α,25-dihydroxyvitamin D"3 ; [abr] 24R,25(OH)"2D"3; 24R,25-dihydroxyvitamin D"3 ; [abr] 25(OH)D"3; 25-hydroxyvitamin D"3 ; [abr] DMSO; dimethyl sulfoxide ; [abr] HL-60; a human promyelocytic leukemia cell line ; [abr] Ml; a murine myeloblastic leukemia cell line ; [abr] TPA; 12-O-tetradecanoylphorbol-13-acetate ; [abr] U937; a human histiocytic monoblast-like lymphoma cell line
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0006-291X(84)80322-8
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  • 3
    Electronic Resource
    Electronic Resource
    Inhibition by 1α, 25-dihydroxyvitamin D"3 of dimethyl sulfoxide-induced differentiation of friend erythroleukemia cells
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 119 (1984), S. 807-813 
    Details
    ISSN: 0006-291X
    Keywords: [abr] 1α(OH)D"3; 1α-hydroxyvitamin D"3 ; [abr] 1α,25(OH)"2D"3; 1α,25-dihydroxyvitamin D"3 ; [abr] 24R,25(OH)"2D"3; 24R,25-dihydroxyvitamin D"3 ; [abr] 25(OH)D"3; 25-hydroxyvitamin D"3 ; [abr] DMSO; dimethyl sulfoxide ; [abr] HL-60; a human promyelocytic leukemia cell line ; [abr] Ml; a murine myeloblastic leukemia cell line ; [abr] TPA; 12-O-tetradecanoylphorbol-13-acetate ; [abr] U937; a human histiocytic monoblast-like lymphoma cell line
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0006-291X(84)80322-8
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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