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  • 1
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    Facultative cheater mutants reveal the genetic complexity of cooperation in social amoebae (2008)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2008-02-15
    Description: Cooperation is central to many major transitions in evolution, including the emergence of eukaryotic cells, multicellularity and eusociality. Cooperation can be destroyed by the spread of cheater mutants that do not cooperate but gain the benefits of cooperation from others. However, cooperation can be preserved if cheaters are facultative, cheating others but cooperating among themselves. Several cheater mutants have been studied before, but no study has attempted a genome-scale investigation of the genetic opportunities for cheating. Here we describe such a screen in a social amoeba and show that cheating is multifaceted by revealing cheater mutations in well over 100 genes of diverse types. Many of these mutants cheat facultatively, producing more than their fair share of spores in chimaeras, but cooperating normally when clonal. These findings indicate that phenotypically stable cooperative systems may nevertheless harbour genetic conflicts. The opportunities for evolutionary moves and countermoves in such conflicts may select for the involvement of multiple pathways and numerous genes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Santorelli, Lorenzo A -- Thompson, Christopher R L -- Villegas, Elizabeth -- Svetz, Jessica -- Dinh, Christopher -- Parikh, Anup -- Sucgang, Richard -- Kuspa, Adam -- Strassmann, Joan E -- Queller, David C -- Shaulsky, Gad -- G0400103/Medical Research Council/United Kingdom -- Wellcome Trust/United Kingdom -- England -- Nature. 2008 Feb 28;451(7182):1107-10. doi: 10.1038/nature06558. Epub 2008 Feb 13.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Ecology and Evolutionary Biology, Rice University, Houston, Texas 77005, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18272966" target="_blank"〉PubMed〈/a〉
    Keywords: Amoeba/genetics/physiology ; Animals ; Cell Aggregation ; Chimera/genetics/physiology ; *Cooperative Behavior ; Dictyostelium/cytology/*genetics/*physiology ; Genes, Protozoan/genetics ; Genome/genetics ; Genomics ; Mutation/*genetics ; Myxococcus xanthus/genetics/physiology ; Phenotype ; *Social Behavior ; Spores, Protozoan/genetics/physiology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 2
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    Self-recognition in social amoebae is mediated by allelic pairs of tiger genes (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-06-28
    Description: Free-living cells of the social amoebae Dictyostelium discoideum can aggregate and develop into multicellular fruiting bodies in which many die altruistically as they become stalk cells that support the surviving spores. Dictyostelium cells exhibit kin discrimination--a potential defense against cheaters, which sporulate without contributing to the stalk. Kin discrimination depends on strain relatedness, and the polymorphic genes tgrB1 and tgrC1 are potential components of that mechanism. Here, we demonstrate a direct role for these genes in kin discrimination. We show that a matching pair of tgrB1 and tgrC1 alleles is necessary and sufficient for attractive self-recognition, which is mediated by differential cell-cell adhesion. We propose that TgrB1 and TgrC1 proteins mediate this adhesion through direct binding. This system is a genetically tractable ancient model of eukaryotic self-recognition.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142563/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142563/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hirose, Shigenori -- Benabentos, Rocio -- Ho, Hsing-I -- Kuspa, Adam -- Shaulsky, Gad -- F31 GM086131/GM/NIGMS NIH HHS/ -- R01 GM084992/GM/NIGMS NIH HHS/ -- R01 GM084992-03/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2011 Jul 22;333(6041):467-70. doi: 10.1126/science.1203903. Epub 2011 Jun 23.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21700835" target="_blank"〉PubMed〈/a〉
    Keywords: Alleles ; Amino Acid Sequence ; *Cell Adhesion ; Cell Aggregation ; Dictyostelium/*genetics/*physiology ; Gene Deletion ; *Genes, Protozoan ; Molecular Sequence Data ; Protein Binding ; Protozoan Proteins/*metabolism ; Spores, Protozoan/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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