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  • 1
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    Evidence for mating of the "asexual" yeast Candida albicans in a mammalian host (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-07-15
    Description: Since its classification nearly 80 years ago, the human pathogen Candida albicans has been designated as an asexual yeast. In this report, we describe the construction of C. albicans strains that were subtly altered at the mating-type-like (MTL) locus, a cluster of genes that resembles the mating-type loci of other fungi. These derivatives were capable of mating after inoculation into a mammalian host. C. albicans is a diploid organism, but most of the mating products isolated from a mouse host were tetrasomic for the two chromosomes that could be rigorously monitored and, overall, exhibited substantially higher than 2n DNA content. These observations demonstrated that C. albicans can recombine sexually.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hull, C M -- Raisner, R M -- Johnson, A D -- GM37049/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2000 Jul 14;289(5477):307-10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology and Immunology and Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10894780" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Candida albicans/*physiology ; Conjugation, Genetic ; Female ; *Genes, Fungal ; *Genes, Mating Type, Fungal ; Homeodomain Proteins/genetics ; Humans ; Mice ; Multigene Family ; Ploidies ; *Recombination, Genetic ; Repressor Proteins/genetics ; *Saccharomyces cerevisiae Proteins
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Identification of a mating type-like locus in the asexual pathogenic yeast Candida albicans (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-08-24
    Description: Candida albicans, the most prevalent fungal pathogen in humans, is thought to lack a sexual cycle. A set of C. albicans genes has been identified that corresponds to the master sexual cycle regulators a1, alpha1, and alpha2 of the Saccharomyces cerevisiae mating-type (MAT) locus. The C. albicans genes are arranged in a way that suggests that these genes are part of a mating type-like locus that is similar to the mating-type loci of other fungi. In addition to the transcriptional regulators a1, alpha1, and alpha2, the C. albicans mating type-like locus contains several genes not seen in other fungal MAT loci, including those encoding proteins similar to poly(A) polymerases, oxysterol binding proteins, and phosphatidylinositol kinases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hull, C M -- Johnson, A D -- GM37049/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1999 Aug 20;285(5431):1271-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10455055" target="_blank"〉PubMed〈/a〉
    Keywords: 1-Phosphatidylinositol 4-Kinase/genetics ; Amino Acid Sequence ; Candida albicans/chemistry/*genetics/physiology ; Gene Deletion ; *Gene Expression Regulation, Fungal ; *Genes, Fungal ; *Genes, Mating Type, Fungal ; Homeodomain Proteins/chemistry/*genetics/metabolism ; Introns ; Molecular Sequence Data ; Open Reading Frames ; Operator Regions, Genetic ; Polynucleotide Adenylyltransferase/genetics ; Receptors, Steroid/genetics ; Recombination, Genetic ; Repressor Proteins/chemistry/*genetics/metabolism ; Saccharomyces cerevisiae/chemistry/genetics ; *Saccharomyces cerevisiae Proteins ; Transcription, Genetic ; Transformation, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
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