Publication Date:
1999-03-12
Description:
Segregation Distorter (SD) in Drosophila melanogaster is a naturally occurring meiotic drive system in which the SD chromosome is transmitted from SD/SD+ males in vast excess over its homolog owing to the induced dysfunction of SD+-bearing spermatids. The Sd locus is the key distorting gene responsible for this phenotype. A genomic fragment from the Sd region conferred full distorting activity when introduced into the appropriate genetic background by germline transformation. The only functional product encoded by this fragment is a truncated version of the RanGAP nuclear transport protein. These results demonstrate that this mutant RanGAP is the functional Sd product.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Merrill, C -- Bayraktaroglu, L -- Kusano, A -- Ganetzky, B -- New York, N.Y. -- Science. 1999 Mar 12;283(5408):1742-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Genetics, 445 Henry Mall, University of Wisconsin, Madison, WI 53706, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10073941" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Carrier Proteins/chemistry/*genetics/physiology
;
Cell Nucleus/metabolism
;
Crosses, Genetic
;
DNA, Complementary
;
*Drosophila Proteins
;
Drosophila melanogaster/*genetics/physiology
;
Female
;
*GTPase-Activating Proteins
;
Gene Duplication
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Gene Expression
;
*Genes, Insect
;
Male
;
*Meiosis
;
Nuclear Proteins/chemistry/*genetics/physiology
;
RNA, Messenger/genetics
;
Spermatids/physiology
;
Sulfotransferases/chemistry/genetics
;
Transcription, Genetic
;
Transformation, Genetic
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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