Publication Date:
2000-10-29
Description:
Until now, genome-wide transcriptional profiling has been limited to single-cell organisms. The nematode Caenorhabditis elegans is a well-characterized metazoan in which the expression of all genes can be monitored by oligonucleotide arrays. We used such arrays to quantitate the expression of C. elegans genes throughout the development of this organism. The results provide an estimate of the number of expressed genes in the nematode, reveal relations between gene function and gene expression that can guide analysis of uncharacterized worm genes, and demonstrate a shift in expression from evolutionarily conserved genes to worm-specific genes over the course of development.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hill, A A -- Hunter, C P -- Tsung, B T -- Tucker-Kellogg, G -- Brown, E L -- New York, N.Y. -- Science. 2000 Oct 27;290(5492):809-12.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Genomics, Genetics Institute, Cambridge, MA 02140, USA. ahill@genetics.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11052945" target="_blank"〉PubMed〈/a〉
Keywords:
Analysis of Variance
;
Animals
;
Caenorhabditis elegans/*genetics/growth & development
;
Databases, Factual
;
Down-Regulation
;
*Gene Expression
;
*Gene Expression Profiling
;
*Genes, Helminth
;
*Genome
;
Models, Genetic
;
Multigene Family
;
Oligonucleotide Array Sequence Analysis
;
Open Reading Frames
;
Up-Regulation
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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