Publication Date:
2010-01-16
Description:
Mouse models are useful for studying genes involved in behavior, but whether they are relevant to human behavior is unclear. Here, we identified parallel phenotypes in mice and humans resulting from a common single-nucleotide polymorphism in the brain-derived neurotrophic factor (BDNF) gene, which is involved in anxiety-related behavior. An inbred genetic knock-in mouse strain expressing the variant BDNF recapitulated the phenotypic effects of the human polymorphism. Both were impaired in extinguishing a conditioned fear response, which was paralleled by atypical frontoamygdala activity in humans. Thus, this variant BDNF allele may play a role in anxiety disorders showing impaired learning of cues that signal safety versus threat and in the efficacy of treatments that rely on extinction mechanisms, such as exposure therapy.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2829261/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2829261/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Soliman, Fatima -- Glatt, Charles E -- Bath, Kevin G -- Levita, Liat -- Jones, Rebecca M -- Pattwell, Siobhan S -- Jing, Deqiang -- Tottenham, Nim -- Amso, Dima -- Somerville, Leah H -- Voss, Henning U -- Glover, Gary -- Ballon, Douglas J -- Liston, Conor -- Teslovich, Theresa -- Van Kempen, Tracey -- Lee, Francis S -- Casey, B J -- GM07739/GM/NIGMS NIH HHS/ -- HD055177/HD/NICHD NIH HHS/ -- MH060478/MH/NIMH NIH HHS/ -- MH079513/MH/NIMH NIH HHS/ -- NS052819/NS/NINDS NIH HHS/ -- P50 MH079513/MH/NIMH NIH HHS/ -- P50 MH079513-01A1/MH/NIMH NIH HHS/ -- P50 MH079513-01A10001/MH/NIMH NIH HHS/ -- P50 MH079513-02/MH/NIMH NIH HHS/ -- P50 MH079513-020001/MH/NIMH NIH HHS/ -- R01 MH091864/MH/NIMH NIH HHS/ -- R01 NS052819/NS/NINDS NIH HHS/ -- R01 NS052819-05/NS/NINDS NIH HHS/ -- R25 MH060478/MH/NIMH NIH HHS/ -- R25 MH060478-10/MH/NIMH NIH HHS/ -- T32 GM007739/GM/NIGMS NIH HHS/ -- T32 GM007739-30/GM/NIGMS NIH HHS/ -- T32 HD055177/HD/NICHD NIH HHS/ -- T32 HD055177-01A2/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 2010 Feb 12;327(5967):863-6. doi: 10.1126/science.1181886. Epub 2010 Jan 14.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉The Sackler Institute for Developmental Psychobiology, Weill Cornell Medical College, New York, NY 10065, USA. fas2002@med.cornell.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20075215" target="_blank"〉PubMed〈/a〉
Keywords:
Adolescent
;
Adult
;
Alleles
;
Amygdala/physiology
;
Animals
;
Brain Mapping
;
Brain-Derived Neurotrophic Factor/*genetics/*physiology
;
*Conditioning, Classical
;
Cues
;
Ethnic Groups/genetics
;
*Extinction, Psychological
;
*Fear
;
Female
;
Gene Knock-In Techniques
;
Genotype
;
Humans
;
Magnetic Resonance Imaging
;
Male
;
Mice
;
*Polymorphism, Single Nucleotide
;
Prefrontal Cortex/physiology
;
Young Adult
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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