Publikationsdatum:
1997-11-05
Beschreibung:
When transgenic mice that expressed human sickle hemoglobin were mated with mice having knockout mutations of the mouse alpha- and beta-globin genes, animals were produced that synthesized only human hemoglobin in adult red blood cells. Similar to many human patients with sickle cell disease, the mice developed a severe hemolytic anemia and extensive organ pathology. Numerous sickled erythrocytes were observed in peripheral blood. Although chronically anemic, most animals survived for 2 to 9 months and were fertile. Drug and genetic therapies can now be tested in this mouse model of sickle cell disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ryan, T M -- Ciavatta, D J -- Townes, T M -- CA13148/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1997 Oct 31;278(5339):873-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry and Molecular Genetics, Schools of Medicine and Dentistry, University of Alabama at Birmingham, Birmingham, AL 35294, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9346487" target="_blank"〉PubMed〈/a〉
Schlagwort(e):
*Anemia, Sickle Cell/blood/genetics/pathology
;
Animals
;
Chromatography, High Pressure Liquid
;
Crosses, Genetic
;
*Disease Models, Animal
;
Erythrocytes/pathology
;
Globins/genetics
;
Hemoglobin, Sickle/genetics
;
Hemoglobins/genetics
;
Humans
;
Mice
;
Mice, Inbred C57BL
;
Mice, Knockout
;
Mice, Transgenic
Print ISSN:
0036-8075
Digitale ISSN:
1095-9203
Thema:
Biologie
,
Chemie und Pharmazie
,
Informatik
,
Medizin
,
Allgemeine Naturwissenschaft
,
Physik
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