Publication Date:
2008-02-02
Description:
Recombination plays a crucial role in meiosis, ensuring the proper segregation of chromosomes. Recent linkage disequilibrium (LD) and sperm-typing studies suggest that recombination rates vary tremendously across the human genome, with most events occurring in narrow "hotspots." To examine variation in fine-scale recombination patterns among individuals, we used dense, genome-wide single-nucleotide polymorphism data collected in nuclear families to localize crossovers with high spatial resolution. This analysis revealed that overall recombination hotspot usage is similar in males and females, with individual hotspots often active in both sexes. Across the genome, roughly 60% of crossovers occurred in hotspots inferred from LD studies. Notably, however, we found extensive and heritable variation among both males and females in the proportion of crossovers occurring in these hotspots.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Coop, Graham -- Wen, Xiaoquan -- Ober, Carole -- Pritchard, Jonathan K -- Przeworski, Molly -- GM83098/GM/NIGMS NIH HHS/ -- HD21244/HD/NICHD NIH HHS/ -- HG002772/HG/NHGRI NIH HHS/ -- HL56399/HL/NHLBI NIH HHS/ -- HL56533/HL/NHLBI NIH HHS/ -- R01 HG002772/HG/NHGRI NIH HHS/ -- New York, N.Y. -- Science. 2008 Mar 7;319(5868):1395-8. doi: 10.1126/science.1151851. Epub 2008 Jan 31.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Human Genetics, University of Chicago, 920 East 58th Street, Cummings Life Science Center, Chicago, IL 60637, USA. gcoop@uchicago.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18239090" target="_blank"〉PubMed〈/a〉
Keywords:
*Crossing Over, Genetic
;
Female
;
Genetic Variation
;
*Genome, Human
;
Genotype
;
Haplotypes
;
Humans
;
Linkage Disequilibrium
;
Male
;
Maternal Age
;
Meiosis
;
Paternal Age
;
Pedigree
;
Polymorphism, Single Nucleotide
;
*Recombination, Genetic
;
Sex Characteristics
;
Transcription Initiation Site
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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