Publikationsdatum:
1983-09-23
Beschreibung:
Neurotransmitter receptors may be involved in a number of neuropsychiatric disease states. The ligand 3-N-[11C]methylspiperone, which preferentially binds to dopamine receptors in vivo, was used to image the receptors by positron emission tomography scanning in baboons and in humans. This technique holds promise for noninvasive clinical studies of dopamine receptors in humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wagner, H N Jr -- Burns, H D -- Dannals, R F -- Wong, D F -- Langstrom, B -- Duelfer, T -- Frost, J J -- Ravert, H T -- Links, J M -- Rosenbloom, S B -- Lukas, S E -- Kramer, A V -- Kuhar, M J -- CA09199/CA/NCI NIH HHS/ -- CA32845/CA/NCI NIH HHS/ -- NS15080/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1983 Sep 23;221(4617):1264-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6604315" target="_blank"〉PubMed〈/a〉
Schlagwort(e):
Animals
;
Brain/metabolism/*radionuclide imaging
;
*Butyrophenones
;
Caudate Nucleus/metabolism
;
Cerebellum/metabolism
;
Humans
;
Papio
;
Receptors, Dopamine/*metabolism
;
*Spiperone/analogs & derivatives
;
Tomography, Emission-Computed/*methods
Print ISSN:
0036-8075
Digitale ISSN:
1095-9203
Thema:
Biologie
,
Chemie und Pharmazie
,
Informatik
,
Medizin
,
Allgemeine Naturwissenschaft
,
Physik
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