Publication Date:
2003-11-01
Description:
Genetic factors play a major role in the etiology of adult-onset neurodegenerative and neuropsychiatric disorders. Several highly penetrant genes have been cloned for rare, autosomal-dominant, early-onset forms of neurodegenerative diseases. These genes have provided important insights into the mechanisms of these diseases (often altering neuronal protein processing). However, the genes associated with inherited susceptibility to late-onset neurodegenerative diseases, schizophrenia, and bipolar disorder appear to have smaller effects and are likely to interact with each other (and with nongenetic factors) to modulate susceptibility and/or disease phenotype. Several strategies have recently been applied to address this complexity, leading to the identification of a number of candidate susceptibility loci/genes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kennedy, James L -- Farrer, Lindsay A -- Andreasen, Nancy C -- Mayeux, Richard -- St George-Hyslop, Peter -- AG07232/AG/NIA NIH HHS/ -- AG15473/AG/NIA NIH HHS/ -- MH31593/MH/NIMH NIH HHS/ -- MH40856/MH/NIMH NIH HHS/ -- MH43271/MH/NIMH NIH HHS/ -- P30-AG95004/AG/NIA NIH HHS/ -- R01-AG09029/AG/NIA NIH HHS/ -- U01-AG17173/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 2003 Oct 31;302(5646):822-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Departments of Psychiatry and Medicine, Centre for Addiction and Mental Health, Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario M5S 3H9, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14593167" target="_blank"〉PubMed〈/a〉
Keywords:
Adult
;
Alzheimer Disease/genetics
;
Bipolar Disorder/genetics
;
Chromosome Mapping
;
Dementia/genetics
;
Genetic Heterogeneity
;
Genetic Linkage
;
*Genetic Predisposition to Disease
;
Humans
;
Mental Disorders/*genetics
;
Middle Aged
;
*Multifactorial Inheritance
;
Neuregulin-1/genetics
;
Neurodegenerative Diseases/*genetics
;
Phenotype
;
Schizophrenia/genetics
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink
