Publication Date:
2008-10-25
Description:
Studies of nitric oxide over the past two decades have highlighted the fundamental importance of gaseous signaling molecules in biology and medicine. The physiological role of other gases such as carbon monoxide and hydrogen sulfide (H2S) is now receiving increasing attention. Here we show that H2S is physiologically generated by cystathionine gamma-lyase (CSE) and that genetic deletion of this enzyme in mice markedly reduces H2S levels in the serum, heart, aorta, and other tissues. Mutant mice lacking CSE display pronounced hypertension and diminished endothelium-dependent vasorelaxation. CSE is physiologically activated by calcium-calmodulin, which is a mechanism for H2S formation in response to vascular activation. These findings provide direct evidence that H2S is a physiologic vasodilator and regulator of blood pressure.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2749494/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2749494/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yang, Guangdong -- Wu, Lingyun -- Jiang, Bo -- Yang, Wei -- Qi, Jiansong -- Cao, Kun -- Meng, Qinghe -- Mustafa, Asif K -- Mu, Weitong -- Zhang, Shengming -- Snyder, Solomon H -- Wang, Rui -- DA00074/DA/NIDA NIH HHS/ -- K05 DA000074/DA/NIDA NIH HHS/ -- K05 DA000074-29/DA/NIDA NIH HHS/ -- MH18501/MH/NIMH NIH HHS/ -- R37 MH018501/MH/NIMH NIH HHS/ -- R37 MH018501-40/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2008 Oct 24;322(5901):587-90. doi: 10.1126/science.1162667.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physiology, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18948540" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Aorta/metabolism
;
*Blood Pressure
;
Calcium/metabolism
;
Calmodulin/metabolism
;
Cystathionine gamma-Lyase/deficiency/genetics/*metabolism
;
Cysteine/blood
;
Endothelium, Vascular/metabolism
;
Homocysteine/blood
;
Hydrogen Sulfide/blood/*metabolism
;
Hypertension/*physiopathology
;
Mesenteric Arteries/physiology
;
Methacholine Chloride/pharmacology
;
Mice
;
Mice, Knockout
;
Myocardium/metabolism
;
Oxidation-Reduction
;
Sulfides/pharmacology
;
*Vasodilation
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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