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  • *Aging  (2)
  • Female  (2)
  • *Receptor Protein-Tyrosine Kinases  (1)
  • 1
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    Aging. Dietary advice on Q (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-01-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tatar, Marc -- Rand, David M -- New York, N.Y. -- Science. 2002 Jan 4;295(5552):54-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA. marc_tatar@brown.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11778030" target="_blank"〉PubMed〈/a〉
    Keywords: *Aging ; Animals ; Caenorhabditis elegans/genetics/growth & development/metabolism/*physiology ; Caenorhabditis elegans Proteins/genetics/physiology ; Cell Nucleus/metabolism ; Diet ; Electron Transport ; Energy Metabolism ; Escherichia coli/metabolism ; Fermentation ; Helminth Proteins/genetics/physiology ; Insulin/metabolism ; Larva/growth & development/metabolism ; *Longevity ; Mitochondria/metabolism ; Mutation ; Reactive Oxygen Species/metabolism ; Receptor, Insulin/genetics/physiology ; Receptors, Cytoplasmic and Nuclear/genetics/physiology ; Signal Transduction ; Ubiquinone/administration & dosage/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-04-09
    Description: The Drosophila melanogaster gene insulin-like receptor (InR) is homologous to mammalian insulin receptors as well as to Caenorhabditis elegans daf-2, a signal transducer regulating worm dauer formation and adult longevity. We describe a heteroallelic, hypomorphic genotype of mutant InR, which yields dwarf females with up to an 85% extension of adult longevity and dwarf males with reduced late age-specific mortality. Treatment of the long-lived InR dwarfs with a juvenile hormone analog restores life expectancy toward that of wild-type controls. We conclude that juvenile hormone deficiency, which results from InR signal pathway mutation, is sufficient to extend life-span, and that in flies, insulin-like ligands nonautonomously mediate aging through retardation of growth or activation of specific endocrine tissue.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tatar, M -- Kopelman, A -- Epstein, D -- Tu, M P -- Yin, C M -- Garofalo, R S -- R01 AG16632/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 2001 Apr 6;292(5514):107-10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Brown University, Providence, RI 02912, USA., University of Massachusetts, Amherst, MA 01003, USA. Marc_Tatar@Brown.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11292875" target="_blank"〉PubMed〈/a〉
    Keywords: Aging/*physiology ; Alleles ; Animals ; Carrier Proteins/*genetics/*physiology ; Corpora Allata/*metabolism ; *Drosophila Proteins ; Drosophila melanogaster/genetics/*physiology ; Female ; Fertility ; Genes, Insect ; Genotype ; Insulin/pharmacology ; Juvenile Hormones/metabolism ; Longevity/*physiology ; Male ; Methoprene/pharmacology ; Mutation ; Protein-Tyrosine Kinases/*genetics/*physiology ; *Receptor Protein-Tyrosine Kinases ; Receptor, Insulin/genetics/physiology ; Reproduction ; Signal Transduction ; Superoxide Dismutase/metabolism ; Triglycerides/metabolism ; Vitellogenesis/drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Comment on "Long-lived Drosophila with overexpressed dFOXO in adult fat body" (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-02-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tatar, Marc -- New York, N.Y. -- Science. 2005 Feb 4;307(5710):675; author reply 675.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Brown University, Division of Biology and Medicine, Box G-W, Providence, RI 02912, USA. marc_tatar@brown.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15692034" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Drosophila Proteins/genetics/*metabolism ; Drosophila melanogaster/genetics/growth & development/*physiology ; Fat Body/*metabolism ; Female ; Forkhead Transcription Factors ; Gene Expression ; *Longevity ; Transcription Factors/genetics/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    The endocrine regulation of aging by insulin-like signals (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-03-01
    Description: Reduced signaling of insulin-like peptides increases the life-span of nematodes, flies, and rodents. In the nematode and the fly, secondary hormones downstream of insulin-like signaling appear to regulate aging. In mammals, the order in which the hormones act is unresolved because insulin, insulin-like growth factor-1, growth hormone, and thyroid hormones are interdependent. In all species examined to date, endocrine manipulations can slow aging without concurrent costs in reproduction, but with inevitable increases in stress resistance. Despite the similarities among mammals and invertebrates in insulin-like peptides and their signal cascade, more research is needed to determine whether these signals control aging in the same way in all the species by the same mechanism.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tatar, Marc -- Bartke, Andrzej -- Antebi, Adam -- New York, N.Y. -- Science. 2003 Feb 28;299(5611):1346-51.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12610294" target="_blank"〉PubMed〈/a〉
    Keywords: *Aging ; Animals ; Caenorhabditis elegans/genetics/physiology ; *Caenorhabditis elegans Proteins ; Caloric Restriction ; Drosophila melanogaster/genetics/physiology ; Endocrine System/*physiology ; Forkhead Transcription Factors ; Gene Expression Regulation ; Growth Hormone/metabolism ; Humans ; Insect Hormones/physiology ; Insulin/*metabolism ; *Longevity ; Mice ; *Signal Transduction ; Somatomedins/*metabolism ; Transcription Factors/genetics/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
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