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  • 1
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    A basal transcription factor that activates or represses transcription (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-11-04
    Description: We have identified an activity that is required for transcription of downstream promoter element (DPE)-containing core promoters in vitro. The purified factor was found to be the Drosophila homolog of the transcriptional repressor known as NC2 or Dr1-Drap1. Purified recombinant dNC2 activates DPE-driven promoters and represses TATA-driven promoters. A mutant version of dNC2 can activate DPE promoters but is unable to repress TATA promoters. Thus, the activation and repression functions are distinct. These studies reveal that NC2 (Dr1-Drap1) is a bifunctional basal transcription factor that differentially regulates gene transcription through DPE or TATA box motifs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Willy, P J -- Kobayashi, R -- Kadonaga, J T -- CA13106/CA/NCI NIH HHS/ -- GM41249/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2000 Nov 3;290(5493):982-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Section of Molecular Biology and Center for Molecular Genetics, University of California, San Diego, La Jolla, CA 92093-0347, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11062130" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Drosophila/*genetics ; Molecular Weight ; Mutation ; Phosphoproteins/chemistry/genetics/isolation & purification/*metabolism ; *Promoter Regions, Genetic ; Protein Subunits ; Recombinant Proteins/metabolism ; TATA Box ; Transcription Factors/chemistry/genetics/isolation & purification/*metabolism ; *Transcription, Genetic ; *Transcriptional Activation
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Yeast origin recognition complex functions in transcription silencing and DNA replication (1993)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1993-12-17
    Description: The genes encoding two of the subunits of the Saccharomyces cerevisiae origin recognition complex (ORC) have been isolated. Characterization of a temperature-sensitive mutation in the gene encoding the 72-kD subunit of ORC (ORC2) indicates that this protein complex functions early in the DNA replication process. Moreover, ORC derived from orc2ts cells is defective for DNA binding. Others have shown a defect in orc2ts cells in transcriptional silencing at the silent mating-type loci. Consistent with this finding, ORC specifically binds to each of the four mating-type silencers identified in yeast. These findings support the hypothesis that ORC acts as an initiator protein at yeast origins of DNA replication and suggest that ORC also functions in the determination of transcriptional domains.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bell, S P -- Kobayashi, R -- Stillman, B -- AI20460/AI/NIAID NIH HHS/ -- CA13106/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1993 Dec 17;262(5141):1844-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cold Spring Harbor Laboratory, NY 11724.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8266072" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; *DNA Replication ; DNA, Fungal/biosynthesis ; *DNA-Binding Proteins ; Fungal Proteins/chemistry/*genetics/metabolism ; *Gene Expression Regulation, Fungal ; Genes, Fungal ; Genes, Mating Type, Fungal ; Molecular Sequence Data ; Mutation ; Origin Recognition Complex ; *Replicon ; Repressor Proteins/chemistry/*genetics/metabolism ; S Phase ; Saccharomyces cerevisiae/cytology/*genetics/metabolism ; Saccharomyces cerevisiae Proteins ; Temperature ; Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
    Electronic Resource
    Electronic Resource
    Purification and characterization of an α-actinin-like protein from porcine kidney
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular 745 (1983), S. 209-216 
    Details
    ISSN: 0167-4838
    Keywords: (Porcine kidney) ; Actinin ; Actinin-like protein ; Cytoskeleton
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0167-4838(83)90051-1
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