Publication Date:
2012-09-29
Description:
A remarkable feature of modern silicon electronics is its ability to remain physically invariant, almost indefinitely for practical purposes. Although this characteristic is a hallmark of applications of integrated circuits that exist today, there might be opportunities for systems that offer the opposite behavior, such as implantable devices that function for medically useful time frames but then completely disappear via resorption by the body. We report a set of materials, manufacturing schemes, device components, and theoretical design tools for a silicon-based complementary metal oxide semiconductor (CMOS) technology that has this type of transient behavior, together with integrated sensors, actuators, power supply systems, and wireless control strategies. An implantable transient device that acts as a programmable nonantibiotic bacteriocide provides a system-level example.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3786576/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3786576/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hwang, Suk-Won -- Tao, Hu -- Kim, Dae-Hyeong -- Cheng, Huanyu -- Song, Jun-Kyul -- Rill, Elliott -- Brenckle, Mark A -- Panilaitis, Bruce -- Won, Sang Min -- Kim, Yun-Soung -- Song, Young Min -- Yu, Ki Jun -- Ameen, Abid -- Li, Rui -- Su, Yewang -- Yang, Miaomiao -- Kaplan, David L -- Zakin, Mitchell R -- Slepian, Marvin J -- Huang, Yonggang -- Omenetto, Fiorenzo G -- Rogers, John A -- EB002520/EB/NIBIB NIH HHS/ -- P41 EB002520/EB/NIBIB NIH HHS/ -- New York, N.Y. -- Science. 2012 Sep 28;337(6102):1640-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23019646" target="_blank"〉PubMed〈/a〉
Keywords:
*Absorbable Implants
;
Animals
;
Anti-Bacterial Agents
;
Electric Power Supplies
;
*Electronics
;
Metals
;
Mice
;
Mice, Inbred BALB C
;
Oxides
;
*Semiconductors
;
*Silicon
;
Transistors, Electronic
;
Wireless Technology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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