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  • Cell & Developmental Biology  (5)
  • SPACE COMMUNICATIONS, SPACECRAFT COMMUNICATIONS, COMMAND AND TRACKING  (2)
  • (Human hepatocyte)  (1)
  • Addition compound  (1)
Collection
Keywords
Publisher
Years
  • 1
    Electronic Resource
    Electronic Resource
    Synthesis of transcobalamin II by cultured human hepatocytes
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/General Subjects 838 (1985), S. 387-389 
    Details
    ISSN: 0304-4165
    Keywords: (Human hepatocyte) ; Cobalamin ; Transcobalamin II synthesis
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0304-4165(85)90239-9
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Structure of the silver imidodi(sulphuryl fluoride)-benzene solvate AgN(SO"2F)"2.C"6H"6
    Amsterdam : Elsevier
    Journal of Organometallic Chemistry 481 (1994), S. 243-246 
    Details
    ISSN: 0022-328X
    Keywords: Addition compound ; Benzene ; Crystal structure ; Imidodi(sulphuryl fluoride) ; Silver
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0022-328X(94)85032-1
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The metabolism of cobalamin bound to transcobalamin II and to glycoproteins that bind Cbl in HepG2 cells (human hepatoma) (1985)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 124 (1985), S. 507-515 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: The binding, internalization, processing and release of labeled cyanocobalamin (CN[57Co]Cbl) bound to human transcobalamin II (TC II) were studied in HepG2 cells, a line of hepatocytes derived from a human hepatoma. The cells bound the TC II-Cbl by specific, high affinity receptors. Within the cell, the CN-Cbl was promptly freed from TC II and the CN-Cbl converted to more active forms including adenosyl Cbl (AdoCbl) and methyl Cbl (MeCbl). Whereas free labeled Cbl was still present at 72 hours after entry, the cells also bound Cbl to an intracellular binder (ICB) presumed to represent the holo enzymes dependent on Cbl. At levels of TC II that saturated the receptors for TC II-Cbl, much of the Cbl entering the cells remained free and was converted to AdoCbl. Under these circumstances the cells released free Cbl, mostly AdoCbl.Human R type binders of Cbl, which are glycoproteins and some having a terminal galactose, were bound by the HepG2 cells. The binding was characteristic of the receptor system responsive to a terminal galactose, or asialoglycoproteins, but was inconsistent and of low affinity. Cbl bound to R binder was internalized and converted to coenzyme forms of Cbl, but the process was much less effective than when the Cbl entered via the TC II receptor system. It was concluded that the receptors for R-Cbl were unlikely to contribute to the physiologic transport of Cbl in man, but may function in some yet unknown way.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1041240322
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  • 4
    Electronic Resource
    Electronic Resource
    Cyclic activity of the receptors of cobalamin bound to transcobalamin II (1987)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 133 (1987), S. 187-191 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: The activity of receptors specific for human transcobalamin II-Cobalamin (TC II-Cbl) were measured in virus-transformed lymphoblasts, hepatocytes (hepatoma) and diploid fibrolasts. In all three types of human cells the receptor activity increased as cells went from a resting phase to the most actively dividing phase. Receptor activity declined as cell division slowed. The changes in activity of lymphoblasts and hepatocytes were produced by changes in receptor numbe and not by changes in affinity between receptors and TC II-Cbl. The basis of the change in fibroblasts was not clear. The Cbl-dependent methionine synthetase activity of fibroblasts, in contrast, tended to be greatest when the cultures were confluent and replication had slowed. As the fibroblasts became senescent the receptor activity for TC II-Cbl declined and the fluctuations with the phase of the cell were blunted. However, the release of apo TC II from the cells was maintained. These observations must be taken into consideration when the respective cells are used as models. Even more important are the implications of the observations of the changes in receptor activity for TC II-Cbl for the regulation of the entry of Cbl into cells.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1041330125
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  • 5
    Electronic Resource
    Electronic Resource
    Induction of heat labile alkaline phosphatase by butyrate in differentiating endometrial cells (1995)
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 58 (1995), S. 509-516 
    Details
    ISSN: 0730-2312
    Keywords: alkaline phosphatase ; Ishikawa endometrial cells ; butyrate ; differentiation ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: The addition of 2mM sodium butyrate to monolayers enhances differentiation of Ishikawa endometrial cells. Cells from this cell line have been shown to enlarge and lift off the dish into dome structure over a period of 24-48 h in response to a factor in fetal bovine serum (FBS) [Fleming, 1995 J Cell Biochem in press]. When butyrate is added to monolayers, together with FBS, three- to fourfold higher numbers of differentiated structures, domes and predomes, can be counted. It had previously been shown [Holinka et al., 1986b] that estradiol induces heat stable placental alkaline phosphatese in lshikawa cells. The addition of butyrate, on the other hand, results in a significant increase in levels of a heat labile alkaline phosphatase isozyme. The heat labile isozyme is also increased to some extent in cells stimulated to differentiate in response to FBS in the absence of butyrate. Differential inhibition by homoarginine and phenylalanine indicates that butyrate is inducing the liver-bone kidney isozyme that is found in endometrial glands in vivo.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcb.240580414
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  • 6
    Electronic Resource
    Electronic Resource
    Cobalamin metabolism in cultured human chorionic villus cells (1993)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 156 (1993), S. 43-47 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Cobalamin (Cbl, vitamin B12) metabolism was analyzed in cultures of human chorionic villus (CV) cells obtained at 9-10 weeks of gestation. CV cells were shown to synthesize transcobalamin II (TCII) and to possess a high affinity receptor for that molecule. The cells bound and internalized radioactive cyanocobalamin (CN[57Co]Cbl) complexed to TCII. This internalized CN[57Co]Cbl was found to be converted to both methylCbl and adenosylCbl, the two intracellular coenzyme forms of Cbl, and bound to the two known intracellular Cbl requiring enzymes, methionine synthase (MS) and methylmalonyl-CoA mutase. Both enzyme systems were found to be functional in the intact cell by demonstrating the incorporation of the radioactive label from both [14C]CH3-tetrahydrofolate and [14C]propionate into acid insoluble products. MS activity was also detected in lysed cell material. CV cells were shown not to be auxotrophic for methionine since they were able to utilize homocysteine in place of methionine for cell division. Since CV cells are capable of performing many of the complex events associated with Cbl metabolism, it may be possible to use these cells to diagnose genetic defects of Cbl metabolism. © 1993 Wiley-Liss, Inc.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1041560107
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  • 7
    Electronic Resource
    Electronic Resource
    The SCL/TAL1 gene: Roles in normal and malignant haematopoiesis (1997)
    New York, NY : Wiley-Blackwell
    BioEssays 19 (1997), S. 607-613 
    Details
    ISSN: 0265-9247
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: SCL (TAL1/TCL5) is a member of the helix-loop-helix family of transcription factors. Originally identified because of its involvement in a tumour-specific chromosomal translocation, overexpression of the SCL gene is the most common molecular abnormality found in human T cell leukaemia. Transgenic models have now formally demonstrated that overexpression of SCL within the T cell lineage is capable of causing malignant transformation. Gene targeting experiments have revealed that the SCL gene is crucial for the development of primitive haematopoiesis in the mouse and is also required for the generation of all adult haematopoietic lineages. Biochemical studies have indicated some of the proteins which interact with SCL and this has refined the hypotheses concerning the mechanisms by which SCL plays a role in leukaemogenesis and haematopoietic development.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bies.950190711
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  • 8
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    Free-space laser communication technologies II; Proceedings of the Meeting, Los Angeles, CA, Jan. 15-17, 1990 (1990)
    In:  Other Sources
    Details
    Publication Date: 2019-07-13
    Description: Various papers on free-space laser communication technologies are presented. Individual topics addressed include: optical intersatellite link experiment between the earth station and ETS-VI, the Goddard optical communications program, technologies and techniques for lasercom terminal size, weight, and cost reduction, laser beam acquisition and tracking system for ETS-VI laser communication equipment, analog dividers for acquisition and tracking signal normalization, fine pointing mechanism using multilayered piezoelectric actuator for optical ISL system, analysis of SILEX tracking sensor performance, new telescope concept for space communication, telescope considered as a very high gain antenna, design of compact transceiver optical systems for optical intersatellite links, ultralightweight optics for laser communications, highly sensitive measurement method for stray light and retroreflected light, depolarization effects on free space laser transceiver communication systems, in-orbit measurements of microaccelerations of ESA's communication satellite Olympus, high-performance laser diode transmitter for optical free space communication, diode-pumped Nd:host laser transmitter for intersatellite optical communications, single-frequency diode-pumped laser for free-space communication.
    Keywords: SPACE COMMUNICATIONS, SPACECRAFT COMMUNICATIONS, COMMAND AND TRACKING
    Type: SPIE-1218 , Free-Space Laser Communication Technologies II; Jan 15, 1990 - Jan 17, 1990; Los Angeles, CA; United States
    Format: text
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    NASA TECHNICAL REPORTS
  • 9
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    Unknown
    Free-space laser communication technologies IV; Proceedings of the 4th Conference, Los Angeles, CA, Jan. 23, 24, 1992 (1992)
    In:  Other Sources
    Details
    Publication Date: 2019-07-13
    Description: Papers included in this volume are grouped under topics of receivers; laser transmitters; components; system analysis, performance, and applications; and beam control (pointing, acquisition, and tracking). Papers are presented on an experimental determination of power penalty contributions in an optical Costas-type phase-locked loop receiver, a resonant laser receiver for free-space laser communications, a simple low-loss technique for frequency-locking lasers, direct phase modulation of laser diodes, and a silex beacon. Particular attention is given to experimental results on an optical array antenna for nonmechanical beam steering, a potassium Faraday anomalous dispersion optical filter, a 100-Mbps resonant cavity phase modulator for coherent optical communications, a numerical simulation of a 325-Mbit/s QPPM optical communication system, design options for an optical multiple-access data relay terminal, CCD-based optical tracking loop design trades, and an analysis of a spatial-tracking subsystem for optical communications.
    Keywords: SPACE COMMUNICATIONS, SPACECRAFT COMMUNICATIONS, COMMAND AND TRACKING
    Type: SPIE-1635 , ; 390 p.
    Format: text
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    NASA TECHNICAL REPORTS
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