ISSN:
0899-0042
Schlagwort(e):
chemoselective reduction
;
disiamylborane
;
(-)-2′-deoxy-3′-thiacytidine
;
(1′R,2′S,5′R)-menthyl-(5R)-acetoxy-1,3-oxathiolan-(2R)-carboxylate
;
Lamivudine
;
3TCTM
;
chiral HPLC
;
chiral stationary phase
;
Pirkle β-GEM 1 column
;
Chemistry
;
Organic Chemistry
Quelle:
Wiley InterScience Backfile Collection 1832-2000
Thema:
Chemie und Pharmazie
Notizen:
Chemoselective reduction of one isomer of the 1-menthylester of 1,3-oxathiolan-5-one-2-carboxylic acid produces a mixture of four lactol diastereomers from which the title compound was isolated after acylation. The isomeric purity and absolute stereochemistry were determined by spectroscopic methods, chiral HPLC techniques, and conversion to (-)-2′-deoxy-3′-thiacytidine (Lamivudine, 3TCTM). © 1994 Wiley-Liss, Inc.
Zusätzliches Material:
5 Ill.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1002/chir.530060217
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