ISSN:
0935-6304
Keywords:
Preparative HPLC
;
Optical purity by HPLC
;
Resolution of enantiomers
;
(-)-Gossypol
;
(+)-Gossypol
;
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Racemic gossypol is resolved by HPLC of its amino acid ester Schiff's base derivatives on non-chiral columns. This provides a rapid and accurate method for determination of optical purity on a small scale and, combined with hydrolysis and fractional crystallization, for the preparation of pure gossypol enantiomers on a multi-gram scale.
Additional Material:
8 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jhrc.1240100207
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