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  • (+)-Cyanidanol  (1)
  • gastrointestinal absorption  (1)
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  • 1
    Electronic Resource
    Electronic Resource
    Lactitol: Gastrointestinal absorption and effect on blood lactate in healthy volunteers and patients with cirrhosis (1988)
    Springer
    European journal of clinical pharmacology 35 (1988), S. 97-99 
    Details
    ISSN: 1432-1041
    Keywords: lactitol ; gastrointestinal absorption ; blood lactate ; cirrhosis ; metabolic effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The gastrointestinal absorption of lactitol has been studied in 6 healthy volunteers and 8 patients with cirrhosis. Following administration of lactitol 0.5 g/kg, no lactitol was found in serum. The urinary excretion of lactitol over 24 h ranged from 0.1 to 1.4% of the administered dose (0.46% in cirrhotics and 0.35% in healthy volunteers). Blood D- and L-lactate and plasma glucose did not increase following lactitol. The data indicate that lactitol was poorly absorbed from the gastrointestinal tract in healthy volunteers and patients with cirrhosis, and that the disaccharide did not disturb glucose or lactate homeostasis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00555516
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  • 2
    Electronic Resource
    Electronic Resource
    The disposition and metabolism of (+)-cyanidanol-3 in patients with alcoholic cirrhosis (1987)
    Springer
    European journal of clinical pharmacology 33 (1987), S. 255-259 
    Details
    ISSN: 1432-1041
    Keywords: cianidanol ; liver cirrhosis ; (+)-Cyanidanol ; metabolism ; disposition ; alcohol abuse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of alcoholic cirrhosis of the liver on the disposition and metabolism of (+)-cyanidanol-3 has been studied in three patients. Following oral intake of U-14C-(+)-cyanidanol-3 2 g, the unchanged drug was detected in plasma between 0.5 and 24 h after dosing and the metabolites, measured only as14C-levels, were still detectable at 120 h. A mean of 55% of the dose was excreted in the urine, in which the major metabolites were the glucuronic and sulphuric acid conjugates of (+)-cyanidanol-3 and 3′-O-methyl-(+)-cyanidanol-3, although one patient excreted a larger proportion as non-conjugated metabolites. The pattern of metabolism in the patients did not differ significantly from that in control subjects, suggesting that the drug is handled by the cirrhotic liver in a similar manner to the normal liver.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00637558
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    Paper (German National Licenses)
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