ISSN:
0006-3592
Keywords:
gene delivery
;
gene therapy
;
generation of guanidines on solid support
;
polyamines
;
polyguanidines
;
Chemistry
;
Biochemistry and Biotechnology
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Biology
,
Process Engineering, Biotechnology, Nutrition Technology
Notes:
The development of new gene delivery technologies is a prerequisite towards gene therapy clinical trials. Because gene delivery mediated by viral vectors remains of limited scope due to immunological and propagation risks, the development of new non-viral gene delivery systems is of crucial importance. We have synthesized a secondary library of mono-functionalized poly-(guanidinium)amines generated from a library of mono-functionalized polyamines applying the concept of “libraries from libraries.” The method allows a quick and easy access to mono-functionalized geometrically varied poly-(guanidinium)amines. The new building blocks were introduced into cationic lipids to obtain novel poly-(guanidinium)amine lipids, which are potential DNA vectors for gene delivery. © 1998 John Wiley & Sons, Inc. Biotechnol Bioeng (Comb Chem) 61:81-87, 1998.
Additional Material:
3 Ill.
Type of Medium:
Electronic Resource
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