ISSN:
0377-0486
Keywords:
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
,
Physics
Notes:
Since the carbonyl stretching modes of membrane phospholipids reflect molecular perturbations and reorganizations at the bilayer interface region, a definitive assignment is desired of the vibrations associated with the carbonyl transitions at either the sn-1 or sn-2 lipid chain position. Ether glycerol phospholipids containing one alkyl ether chain and one acyl chain, with the carbonyl group in either the sn-1 or sn-2 chain, provide lipid systems for establishing these assignments. rac-1-0-Hexadecyl-2-palmitoyl-sn -glycero-3-phosphorylcholine yields a carbonyl stretching mode at 1716 cm-1, while the carbonyl mode for 1-palmitoyl-2-0-hexadecyl-sn -glycero-3-phosphorylcholine shifts to 1737 cm-1, By eliminating the gauche bond at the α-carbon position of the sn-2 acyl chain in 1-0-hexadecyl-2-acetoyl-sn-glycero-3-phosphorylcholine, the lower frequency carbonyl fundamental reverts to a higher frequency (1739 cm-1) characteristic of a nearly trans conformation about the C2—C1 bond in the ester linkage.
Additional Material:
3 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jrs.1250130306
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