Electronic Resource
Weinheim
:
Wiley-Blackwell
Liebigs Annalen
1998 (1998), S. 1543-1548
ISSN:
1434-193X
Keywords:
Enediynes
;
β-Lactams
;
Cycloaromatization
;
Anticancer compounds
;
Lactendiynes
;
Chemistry
;
General Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
New “lactendiynes”, characterized by the fusion at C-4 and N-1 of a β-lactam with a hydroxylated 10-membered cyclic enediyne, were synthesized. Studies on their reactivity have shown that this type of fusion with the azetidinone represents a sufficient “safety-catch” against cycloaromatization. These compounds are relatively reactive toward basic hydrolysis, affording monocyclic enediynes which undergo fast cycloaromatization at room temperature.
Type of Medium:
Electronic Resource
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