ISSN:
0749-1581
Keywords:
EPR
;
Copper complexes
;
Captopril
;
Anti-hypertensive agents
;
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
EPR spectroscopy was used to elucidate the nature of the interaction between copper and the antihypertensive agent 1-[2(S)-3-mercapto-2-methylpropionyl]-L-proline (Captopril) in both solid and aqueous solutions. The EPR spectra indicate that binding to copper(II) occurs via the ligand oxygens rather than the thiol moieties, and that the EPR-detectable copper is greatly reduced on complexation. The EPR parameters for the solid copper(II) complexes are in the range g∥ = 2.374-2.386, g⊥ = 2.076-2.086 and A∥Cu = 13.5 mT, and the parameters for the aqueous solutions are giso = 2.107-2.129 and A∥Cu = 7.1-8.6 mT.
Additional Material:
6 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/mrc.1260270306
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