Publication Date:
2011-08-17
Description:
One new anthracene derivative, juglanthracenoside A ( 1 ), two new anthraquinones, juglanthraquinone A ( 2 ) and juglanthraquinone B ( 3 ), along with a new naturally occurring anthraquinone, 9,10-dihydro-4,8-dihydroxy-9,10-dioxoanthracene-2-carboxylic acid ( 4 ), have been isolated from the stem bark of Juglans mandshurica. Their structures were established by detailed spectroscopic analysis and comparison of the NMR data with those of related compounds. Compound 1 displayed noticeable antioxidant activity in both 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) free radical-scavenging assays, while compound 4 showed strong cytotoxicity against HepG2, SGC7901, HCT-8, and A549 cell lines in vitro.
Print ISSN:
0018-019X
Electronic ISSN:
1522-2675
Topics:
Chemistry and Pharmacology
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