Publication Date:
2014-10-21
Description:
Three new sesquiterpene alcohols, laur-2-ene-3,12-diol ( 1 ), cuparene-3,12-diol ( 2 ), and 8,11-dihydro-1-methoxylaurokamuren-12-ol ( 3 ), along with one known diterpene, kahukuen-10-ol ( 4 ) have been isolated from the organic extract of the red alga Laurencia obtusa. The chemical structures were elucidated on the basis of spectroscopic analysis. The cytotoxicity of the isolated compounds were evaluated against three cancer cell lines, i.e. , KB, HepG2, and MCF-7. Compound 4 exhibited a wide range of cytotoxic activity against KB, HepG2, and MCF-7 cell lines with IC 50 of 0.100, 0.057, and 0.054 μ m, respectively. In addition, 1 showed moderate activities towards KB and MCF-7 cell lines with IC 50 values of 0.171 and 0.184 μ M , respectively and 2 exhibited a moderate activity against KB cell line at a concentration of 0.213 μg/ml. On the other hand, compound 3 exhibited no cytotoxic activity against any of the three cell lines.
Print ISSN:
0018-019X
Electronic ISSN:
1522-2675
Topics:
Chemistry and Pharmacology
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