Publication Date:
2016-03-24
Description:
Deletions linked to TP53 loss drive cancer through p53-independent mechanisms Nature 531, 7595 (2016). doi:10.1038/nature17157 Authors: Yu Liu, Chong Chen, Zhengmin Xu, Claudio Scuoppo, Cory D. Rillahan, Jianjiong Gao, Barbara Spitzer, Benedikt Bosbach, Edward R. Kastenhuber, Timour Baslan, Sarah Ackermann, Lihua Cheng, Qingguo Wang, Ting Niu, Nikolaus Schultz, Ross L. Levine, Alea A. Mills & Scott W. Lowe Mutations disabling the TP53 tumour suppressor gene represent the most frequent events in human cancer and typically occur through a two-hit mechanism involving a missense mutation in one allele and a ‘loss of heterozygosity’ deletion encompassing the other. While TP53 missense mutations can
Print ISSN:
0028-0836
Electronic ISSN:
1476-4687
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
,
Natural Sciences in General
,
Physics
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