Publication Date:
2019
Description:
〈sec〉〈st〉Synopsis〈/st〉〈p〉〈textbox textbox-type="graphic"〉〈p〉〈inline-fig〉〈/inline-fig〉〈/p〉〈/textbox〉〈/p〉
〈p〉We used iNKT transnuclear mice to detect iNKT cells from tissues where they are rare, including adipose, lung, skin-draining lymph nodes, and a previously undescribed population in Peyer's patches that produces IL-4 and helps B-cell class switching to IgG1.〈/p〉
〈p〉 〈l type="unord"〉〈li〉〈p〉iNKT transnuclear mice faithfully model tissue-resident iNKT cell populations.〈/p〉〈/li〉
〈li〉〈p〉iNKT cells are found in Peyer's patches of both wild type and transnuclear mice and can be used as cellular adjuvants for oral vaccination.〈/p〉〈/li〉
〈li〉〈p〉PP-NKT cells produce the majority of the IL-4 in Peyer's patches, and provide indirect help for B-cell class switching to IgG1.〈/p〉〈/li〉〈/l〉 〈/p〉〈/sec〉
Print ISSN:
0261-4189
Electronic ISSN:
1460-2075
Topics:
Biology
,
Medicine
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