Publication Date:
2015-10-16
Description:
Article Phagocytosis of large (but not small) particles requires PI 3-kinase activity. Here, Schlam et al . show that Rho GTPase-activating proteins are recruited to the phagocytic cup by products of PI 3-kinase, resulting in the local inactivation of Rac and Cdc42 and allowing for the completion of internalization of large particles. Nature Communications doi: 10.1038/ncomms9623 Authors: Daniel Schlam, Richard D. Bagshaw, Spencer A. Freeman, Richard F. Collins, Tony Pawson, Gregory D. Fairn, Sergio Grinstein
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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