ISSN:
1573-9171
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The retention of crown compounds in reverse-phase HPLC is determined by their ability to bind to cations present in the eluent. The dependence of the retention of crown compounds on concentration of the binding cation has a break. This enables the stability constant of the crown-compound-cation complex to be calculated. The retention of the antitumor antibiotic actinomycin D in 75% MeOH is demonstrated to depend on [Na+] and not on [K+] for concentrations of the latter from 10−6 to 10−1 M.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00963492
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