ISSN:
1432-1041
Keywords:
methotrexate
;
psoriasis
;
pharmacokinetics
;
p.o.
;
i.m. administration
;
methotrexate steady-state
;
erythrocyte concentration
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary Methotrexate (MTX) concentrations in erythrocytes in 32 psoriatics treated weekly with MTX p.o. or i.m. have been studied. When treatment had been constant for at least 5 weeks, there was only small variation in erythrocyte MTX (ery-MTX) in the week between two courses of treatment. The ery-MTX was correlated with the weekly dose of MTX. For patients treated with MTX i.m.r=0.87, and in patients given divided oral dosesr was 0.68. There was no difference in ery-MTX between the two routes of administration. No correlation was observed between ery-MTX and the total MTX dose or the length of treatment. During constant MTX administration small variations in ery-MTX were observed. Small changes in the weekly dose of MTX resulted in marked changes in ery-MTX in 4 of the 5 patients studied.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00607959
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