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  • 1
    Electronic Resource
    Electronic Resource
    Reconstruction of Extensive Long-Bone Defects in Sheep Using Porous Hydroxyapatite Sponges (1999)
    Springer
    Calcified tissue international 64 (1999), S. 83-90 
    Details
    ISSN: 1432-0827
    Keywords: Key words: Hydroxyapatite — Ceramics — Bone reconstruction — Bone repair — Biomaterials — Orthopedic surgery.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract. The capacity of hydroxyapatite (HA) implants to support large defect repair in weight-bearing long bones of large size animals was investigated. Diaphyseal resections 3.5 cm of the tibia were performed in five adult sheep. They were substituted with HA macroporous ceramic cylinders anatomically shaped, and an external fixator was assembled. The sheep were sacrificed at 20, 40, 60, 120, and 270 days after surgery, respectively. Histology and micro X-ray study of resected implants and adjacent tissues showed proper integration of ceramic with newly formed periosteal bone as early as 20 days after surgery. In one sheep, the external fixator was removed 5 months after surgery. The animal gained the ability to walk with no functional impairment until it was sacrificed 4 months later. At this time, extensive integration of ceramic with bone was detected radiographically and confirmed by a morphological study of the resected sample. Our data indicate that large defects in a weight-bearing long bone can be repaired to the extent necessary for full functional recovery in large animals. These data set the stage for further intervention on material properties as well as for preliminary attempts to use ceramic prostheses for reconstruction of large bone defects in humans.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002239900583
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  • 2
    Electronic Resource
    Electronic Resource
    Computer- and Robot-Assisted Total Knee Replacement: Analysis of a New Surgical Procedure (2000)
    Springer
    Annals of biomedical engineering 28 (2000), S. 1146-1153 
    Details
    ISSN: 1573-9686
    Keywords: Computer-assisted surgery ; Total knee replacement ; TRK ; Planning ; Registration ; Robot ; Knee ; Arthroplasty
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract This paper describes a nonstandard procedure for total knee replacement (TKR), based on the use of modern tools such as computers, electronic sensors, and robots, to achieve accurate and optimal implant results. The intervention is planned on a standard PC connected to the CT scanner. Dedicated software shows the surgeon limb alignment and knee status and assists in the choice of the best prosthesis. The intervention is then performed with a new device and surgical procedure. At first the femur and the tibia are fixed to the operating table with a special clamp and the knee bones are exposed with the standard technique; then the surgeon digitizes the shape of the joint and the computer transfers the planned surgical strategy to a dedicated surgical robot. Resections are performed by the surgeon on a constrained guide held by the robot. In this paper we summarize the main results on the system performances, and discuss the clinical implications of this new technology in the operating room. Preliminary experiments on cadavers and volunteers show that this methodology can improve the accuracy of the implant to 2.5 mm and 2°, reduce operating time and surgical errors, and may represent a challenging alternative methodology for TKR. © 2000 Biomedical Engineering Society. PAC00: 0707Tw, 8780-y
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1114/1.1313774
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