ISSN:
1573-739X
Keywords:
Paclitaxel
;
Taxol®
;
Compatibility
;
Polyvinyl chloride
;
Plasticizer
;
DEHP
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Taxol® solution extracts the plasticizer DEHP (di(2-ethylhexyl)phthalate) from polyvinyl chloride (PVC) materials. In order to minimize patient exposure to DEHP, Taxol® solutions should be prepared and administered in PVC-free materials. Particulate matter may form in Taxol® infusion solution over time, so that in-line filtration with microporous membranes not greater than 0.22 μm is advisable. The purpose of this study was to evaluate the suitability of various administration- and in-line filter-sets for Taxol® application. The extent of leached DEHP was determined using a Reversed Phase HPLC assay specific for DEHP. The four tested administration-sets labeled as PVC-free, were all found to be suitable for Taxol® application. The tested standard PVC-lined administration-set should not be used for Taxol® application. Baxter Intermate® LV 250 can be recommended as a disposable infusion device for ambulatory Taxol® application. It can be connected with all the tested filter sets.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00579710
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