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  • Springer  (20)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of intelligent manufacturing 4 (1993), S. 375-383 
    ISSN: 1572-8145
    Keywords: Process control ; fuzzy logic ; neural network ; frequency trimming ; crystal resonator
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: In the development of a process diagnostic system to monitor the condition of the frequency-trimming process in the production of crystal resonators, fuzzy logic can be applied in the recognition of unnatural statistical patterns in the control charts. The heuristics for reasoning are based on the principles behind statistical process control. Using expert experience and knowledge to troubleshoot the causes of problems, one can associate a characteristic chart pattern with a set of known physical causes. As these causes related to the unnatural statistical patterns are not independent of each other, it is difficult to precisely associate the chart distribution patterns with the known causes. Furthermore, as the trimming process is dynamic, the causes of problems dealt with will vary with time. Hence, by means of neural networks, it is possible to associate fuzzily deduced chart patterns with plausible causes to achieve optimum operating conditions.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1572-8927
    Keywords: Calorimetry ; thermodynamics ; complex formation ; copper dipeptides ; zinc dipeptides ; cadmium dipeptides ; dipeptide complexes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Calorimetric and potentiometric studies have been made at 25°C of the formation of zinc and cadmium complexes of diglycine and of the copper complexes of glycylsarcosine, glycineamide, glycylproline, glycyl-l-alanine, α-alanylglycine, and glycyl-γ-aminobutyric acid. In addition, a potentiometric investigation has been made of the formation of copperl-alanyl-l-alanine complexes. The data have been used to calculate ΔG, ΔH, and ΔS values for all the equilibria involved and, in the case of copper, these data strongly support a common structure for all the mono complexes at lower pH in which the copper is bound to the terminal—NH2 and the oxygen of the peptide group. At higher pH, thermodynamic functions have been determined for the dissociation of the peptide hydrogen atom which is labilized by the copper atom.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-0827
    Keywords: Key words: PTH — Antagonist — Hyperparathyroidism — Humoral hypercalcemia of malignancy — Hypercalcemia.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract. BIM-44002, a pure competitive antagonist of parathyroid hormone (PTH), has a high affinity for the PTH/PTHrP receptor in vitro, and can completely inhibit the actions of a PTH agonist in rats in vivo. Toxicology studies in rats and dogs showed BIM-44002 to be devoid of any adverse effects. Therefore we undertook an investigation to evaluate the potential utility of BIM-44002 in lowering elevated serum calcium in three patients with primary hyperparathyroidism. BIM-44002 was administered by continuous intravenous infusion at dosages of 100 μg/hour (370 nmol/hour) for 12 hours, followed by 200 μg/hour for 12 hours, followed by 400 μg/hour for 12 hours. Vital signs and serum ionized and total calcium were monitored hourly and for 3 hours after cessation of the infusion. Blood for PTH determinations was obtained at the same time points. Serum calcium and PTH did not change during and after the infusion of the antagonist. No subject experienced any adverse reactions to the infusion of the antagonist. We conclude that although the PTH antagonist BIM-44002 was effective both in vitro and in vivo in animals, and it was safe in humans, it was not able to lower serum calcium in patients with hyperparathyroidism. Possible reasons for lack of clinical efficacy are discussed.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1327
    Keywords: Key words Myoglobin ; CO binding ; Time-resolved IR spectroscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract  Myoglobin has long served as a model system for understanding the relations between protein structure, dynamics, and function. Its ability to discriminate between toxic CO and vital O2, two small ligands that are almost equivalent in size and dipole moment, has attracted much attention. To understand discrimination and reversible ligand-binding in Mb, both the bound state and the "docked" state that leads to binding need to be studied. We have reported previously the nearly linear Fe–C–O geometry of bound CO and the nearly orthogonal geometry of docked CO [Lim et al. (1995), Science 269 : 962]. With the exception of X-ray structures, a preponderance of evidence points to a nearly linear Fe–C–O geometry and calls into question the proposal that the highly conserved distal histidine forces CO to bind in a nonoptimal geometry. The differences between the bound CO structures determined using IR and X-ray methods might arise from a water molecule hydrogen bonded to the distal histidine in some of the unit cells. Discrimination by Mb is manifested not only thermodynamically but also kinetically. Time-resolved CO rebinding studies that compare Mb with microperoxidase suggest that the heme pocket docking site in Mb exerts steric control of the ligand rebinding rate, slowing the rate of CO binding by a factor of more than 104.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-203X
    Keywords: Key wordsPersea americana ; Somatic embryogenesis ; Genetic transformation ; Agrobacterium tumefaciens ; Avocado
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Embryogenic avocado cultures were genetically transformed with the uidA (GUS) and nptII genes, and transformed somatic embryos were recovered from these cultures. Embryogenic avocado cultures derived from zygotic embryos of `Thomas' and consisting of proembryonic masses were gently separated and co-cultivated with disarmed, acetosyringone-activated Agrobacterium tumefaciens strain A208, which contained the cointegrative vector pTiT37-ASE::pMON9749 (9749 ASE). Kanamycin-resistant embryogenic suspension cultures were selected in two steps: (1) initial selection in maintenance medium, consisting of MS basal medium, supplemented with 0.1 mg l–1 picloram and 50 mg l–1 kanamycin sulfate for 2–4 months and (2) subsequent selection in maintenance medium with 100 mg/ml kanamycin sulfate for 2 months in order to eliminate chimeras. Somatic embryo maturation was initiated by subculture onto semisolid maturation medium (without picloram) followed by transfer to maturation medium with 100 mg l–1 kanamycin sulfate. Genetic transformation of embryogenic cultures and somatic embryos was confirmed by the X-gluc reaction, and integration of nptII and uidA into the avocado genome was confirmed by PCR and Southern hybridization, respectively.
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Journal of nondestructive evaluation 14 (1995), S. 9-19 
    ISSN: 1573-4862
    Keywords: Nondestructive evaluation ; ultrasonic spectroscopy ; attenuation coefficients ; porosity characterization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract In conventional material evaluation and attenuation measurement, methods employing multiple ultrasonic echoes in the thickness direction of the samples are often used to calculate the reflection and attenuation coefficients. The successive echoes must be well resolved, and there is consequently a minimum thickness of material which can be tested for a given frequency transducer. For thin specimens, a high frequency probe may be used, but this may be problematic for composite laminates since the reflections from the individual plies can cause interference. In this paper, an alternative method based on the amplitude spectrum of the reflections from the specimen is presented. The technique deduces the attenuation coefficients by using the spectral amplitudes at the anti-resonance (or resonance) frequencies of the normalized amplitude spectrum, and has the advantage that it does not require that the successive echoes be separated in time. Measurements made on glass, epoxy, and composite laminate specimens are used to compare our attenuation measurement technique with the standard method.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Acta mechanica 113 (1995), S. 37-52 
    ISSN: 1619-6937
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Summary This study investigates the influence of a cavity on the natural frequencies and mode shapes of a homogeneous, isotropic, elastic solid cylinder. Cavities of different shapes and sizes are often found in engineering applications to provide access, reduce weight and to cut cost in production. As a result, detailed quantitative solutions to this class of problem will be of great interest to engineering practitioners. In this study, a highly efficient and accurate numerical algorithm is proposed to examine the vibrations of elastic solid cylinders with a deep cavity. The technique uses the exact theory of three-dimensional elasticity in conjunction with the Ritz form of minimum energy principle to derive the governing eigenvalue equation. Within the context of three-dimensional elasticity, displacement functions composed of a set of twodimensional lateral surface functions and one-dimensional longitudinal functions are defined for each displacement component. The orthogonality inherent in these functions has resulted in well form eigen value matrices which can be manipulated and solved with ease. The technique yields upper-bound natural frequencies and three-dimensional deformed mode shapes for a wide range of elastic hollow cylinders with an arbitrary cross section. Most of the results presented herein are believed to be new to the existing literature.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Acta mechanica 112 (1995), S. 11-28 
    ISSN: 1619-6937
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Summary This paper presents a formulation for the free vibration analysis of skew Mindlin plates with intermediate parallel stiffeners attached in two directions. The Mindlin theory is used to account for the effects of transverse shear deformations and rotary inertia of the plate while the Engesser theory associated with the consideration of torsion is employed for stiffeners. Based on these two theories, the energy functionals for the plate system have been derived. To obtain the vibration frequencies, these energy functionals are minimized with the shape functions assumed in a set of two-dimensional mathematically complete polynomials. This procedure has been implemented numerically to compute the vibration solutions. Convergence studies have been performed to verify the accuracy of this method. Sets of first known results have been presented for several stiffened plate structures.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Acta mechanica 114 (1996), S. 83-94 
    ISSN: 1619-6937
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Summary This paper investigates the stress intensity factors of two penny-shaped cracks with different sizes in a three-dimensional elastic solid under uniaxial tension. The two cracks are symmetrically parallel located in the isotropic solid. Based on Eshelby's equivalent inclusion method and the superposition pronciple of the elasticity theory, a closed-form analytical elastic solution for the stress intensity factors (SIFs) on the boundaries of the cracks is obtained when the center distance between the two cracks is much larger than the crack sizes. A numerical method is employed to extract the solution for small center distance case. It is found that, due to the interaction between the two cracks, the first and second kinds of SIFs exist at the same time even if the applied stress is pure tension. Numerical examples are given for different configurations and it is clearly shown that the SIFs are strongly determined by the distance between the centers of the two cracks.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Computational optimization and applications 6 (1996), S. 273-291 
    ISSN: 1573-2894
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Abstract Most existing placement algorithms were designed to handle blocks that are rectangular in shape. In this paper, we show how a genetic algorithm (GA) is used to construct an optimal arrangement of two-dimensional rectilinear blocks. Our approach does not require the orientation of each block to be fixed. To transform the placement problem to a GA problem, we devised a decoding technique known as circular placement. The novelty of the circular placement technique is that it configures the rectilinear blocks by building up potentially good groupings of blocks starting from the corners of the placement area. To complement the circular placement approach, we present a methodology for deriving a suitable objective function. We confirm the performance of our GA-based placement algorithm by presenting simulation results of some problems on tiling with up to 128 polyominoes. The algorithm described in this paper has great potential for applications in packing, compacting and general component placement in the various disciplines of engineering.
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