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  • 1
    Electronic Resource
    Electronic Resource
    International Conference on Stochastic Point Processes (1971)
    Springer
    Bulletin of mathematical biology 33 (1971), S. 153-153 
    Details
    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02476671
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  • 2
    Electronic Resource
    Electronic Resource
    The detection and recognition of underground nuclear explosions (1995)
    Springer
    Surveys in geophysics 16 (1995), S. 495-532 
    Details
    ISSN: 1573-0956
    Keywords: Nuclear explosion detection and recognition ; Seismology ; Remote sensing ; Radioactivity ; Ionospheric effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract This paper reports on a joint meeting of the Royal Astronomical Society's Joint Association for Geophysics and VERTIC (the Verification Technology Information Centre) held in London in 1992. The topics presented focused on the detection and recognition of underground nuclear explosions. The objective of the meeting was to emphasize the multi-methodological approach that is important in verifying compliance with test-ban treaties. An overview of seismological monitoring was followed by a discussion of the technical and scientific aspects of a global seismic monitoring network, and in particular of the 1991 experiment to test the large-scale international exchange of seismic data between recording stations and data centres world-wide. The current capabilities of satellite remote-sensing were presented, and their use explained in terms of both the provision of information for monitoring the development of foreign nuclear testing programmes and also for providing sufficient information for the evaluation of treaty compliance. A review of radio-isotope sampling showed how the isotopic signature of both air and ground based sampling programmes can be diagnostic of the nuclear source. Finally, previously classified research on the ionospheric effects of underground nuclear explosions was presented, the generated acoustic waves disturbing the ionosphere and producing detectable changes in the reflection of radio and radar signals which have potential as a monitoring technique.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00665683
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  • 3
    Electronic Resource
    Electronic Resource
    A device for intracerebroventricular injections in the conscious rabbit (1975)
    Springer
    Cellular and molecular life sciences 31 (1975), S. 997-998 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Die Konstruktion und der Gebrauch einer Vorrichtung zur Injektion von Substanzen in den lateralen, cerebralen Ventrikel von wachen Kaninchen wird beschrieben.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02358901
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  • 4
    Electronic Resource
    Electronic Resource
    Staining of sulphatides in metachromatic leukodystrophy with Alcian blue at high salt concentrations (1975)
    Springer
    Histochemistry and cell biology 43 (1975), S. 269-273 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Alcian blue combines with purified sulphatide in 1.OM magnesium chloride. In tissue sections from patients with metachromatic leukodystrophy, sulphatide is stained by Alcian blue in 0.8 M magnesium chloride, and the staining can be abolished by prior treatment with chloroform and methanol. The simplicity of the technique, its specificity and ease of interpretation recommend Alcian blue staining at high salt concentrations as a routine method in the diagnosis of metachromatic leukodystrophy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00499708
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  • 5
    Electronic Resource
    Electronic Resource
    A convenient buffer system for controlled staining with basic dyes (1962)
    Springer
    Histochemistry and cell biology 2 (1962), S. 423-426 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A new buffer system is described for use in histochemical staining with basic dyes. The buffer is made up by mixing solutions of formic acid and sodium acetate. Tables giving the proportions for closely-spaced pH values in the range 3.0–5.6 are presented. A table for an acid phosphate series down to a pH of 2.0 is also included. The value of these buffer mixtures in histological as well as histochemical staining with basic dyes is stressed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00736497
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  • 6
    Electronic Resource
    Electronic Resource
    Histochemical demonstration of carbohydrates by a convenient sulphation technique (1959)
    Springer
    Histochemistry and cell biology 1 (1959), S. 391-402 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Zusammenfassung Es wird eine einfache und handliche Methode zur Darstellung von Kohlenhydratderivaten in Gewebsschnitten beschrieben. Entparaffinierte Schnitte werden 10–15 min in einem 1:1 Essigsäure-Schwefelsäure-Gemisch bzw. durch Behandlung mit Sulfurylchloriddampf während 15–20 min sulfatiert und anschließend mit einer 0,5%igen Methylenblaulösung (gepuffert aufph 2,4) gefärbt. Man erhält eine stark selektive Färbung der Gewebskohlenhydrate. Das Essigsäure-Schwefelsäure-Gemisch hydrolysiert und entfernt das Glykogen sehr rasch. Demgegenüber ist nach Sulfurylchloridbehandlung eine starke Anfärbung von Glykogen möglich. Die einzelnen Schritte der Technik werden diskutiert, besonders die Gründe, die uns bei der endgültigen Wahl der Methodik geleitet haben. Die Methode bietet verschiedene Vorteile gegenüber der PAS-Reaktion: Das Übersichtsbild ist klarer, die Schärfe ist bei starken Vergrößerungen oft besser; die Plastizität der Methode ermöglicht es, Sulfatierung und Färbung den Bedürfnissen verschiedener Probleme anzupassen.
    Notes: Summary A simple and convenient procedure has been devised for the staining of carbohydrate derivatives in tissue sections. Dewaxed sections are sulphated either by immersion in a 1:1 acetic-sulphuric acid mixture for 10–15 minutes or by exposure to sulphuryl chloride vapour for 15–20 minutes. The slides are then stained in a 0.05% solution of methylene blue buffered to aph of 2.4. Highly selective staining of tissue carbohydrates is obtained. The acetic-sulphuric mixture rapidly hydrolyses glycogen which is therefore lost, but the sulphuryl chloride technique produces intense staining of glycogen. The various steps in the technique are discussed, with particular emphasis on the reasons for the final choice of conditions. These sulphation techniques have several advantages over the PAS procedure: the overall picture obtained is clearer; definition at high magnifications is often better; and the versatility of the technique can be widened by varying the precise conditions of sulphation and staining to suit the particular problem being studied.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00736398
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  • 7
    Electronic Resource
    Electronic Resource
    The influence of fixation on staining of glycosaminoglycans in glial cells (1975)
    Springer
    Histochemistry and cell biology 41 (1975), S. 275-279 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Cytoplasmic staining of glial cells by Alcian blue in 0.40 M magnesium chloride can be demonstrated in sections of brain tissue fixed in formol-acetic acid and in Bouin's solution. Phosphate-buffered aldehyde fixatives, whether at neutral or low pH, fail to preserve stainable material.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00497691
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  • 8
    Electronic Resource
    Electronic Resource
    Clinical evaluation of indoramin, a new antihypertensive agent (1973)
    Springer
    European journal of clinical pharmacology 6 (1973), S. 211-216 
    Details
    ISSN: 1432-1041
    Keywords: Antihypertensive therapy ; alpha adrenoceptor blockade
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Indoramin, a new antihypertensive drug shown to have cardioinhibitory and alpha adrenoceptor blocking activity in animals, was administered to patients with benign essential hypertension. Single oral doses between 0.1 and 1.0 mg/kg produced dose dependent falls in diastolic arterial pressure without increasing the heart rate. The arterial pressure response to intravenous noradrenaline was diminished in patients taking indoramin, but the response to intravenous angiotensin II and heart rate responses to intravenous isoprenaline were unaltered. Double blind cross-over comparison of indoramin with placebo in 8 patients on continuous oral therapy at maximally tolerated doses, 60–150 mg daily, showed that indoramin significantly lowered diastolic arterial pressure, but that the falls were modest, 7.6 mm Hg lying, 7.1 mm Hg standing and 9.3 mm Hg after exercise. The dose limiting side effect was sedation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00644733
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  • 9
    Electronic Resource
    Electronic Resource
    Amino acid differences between the α-chains from two hemoglobins of the yellow-cheeked vole (family cricetidae) (1976)
    Springer
    Biochemical genetics 14 (1976), S. 809-821 
    Details
    ISSN: 1573-4927
    Keywords: hemoglobin ; Microtus xanthognathus ; Cricetidae ; tryptic peptides
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract The yellow-cheeked vole (Microtus xanthognathus) shows two electrophoretic hemoglobin components. Electrophoresis of the polypeptide chains from the separated hemoglobin components shows identical β-chains but two α-chains of different mobility, α f and α s . The composition of soluble tryptic peptides was determined for each α-chain. Amino acid differences were found in peptides αT1 and αT9; the compositions of the remainder of the homologous peptides were identical. Differences in αT1, found at α4 (α s -Gly-α f -Val) and α5 (α s -Thr-α f -Asp), were confirmed after a run to residue 20 of the fast component in an automatic sequencer. The differences in charge between αT1 peptides can account for the electrophoretic pattern of two hemoglobins. This is the first time that it has been possible to identity the residues which can account for the charge difference between the two hemoglobins observed in a Microtus species.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00485343
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  • 10
    Electronic Resource
    Electronic Resource
    Multiple-population versus hierarchical conifer breeding programs: a comparison of genetic diversity levels (1995)
    Springer
    Theoretical and applied genetics 90 (1995), S. 584-594 
    Details
    ISSN: 1432-2242
    Keywords: Multiple-population breeding (MPBS) Hierarchical open-ended breeding (HOPE) Genetic conservation ; Conifers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Advanced-generation domestication programs for forest-tree species has raised some concerns about the maintenance of genetic diversity in forest-tree breeding programs. Genetic diversity in natural stands was compared with two genetic conservation options for a third-generation elite Pinus taeda breeding population. The breeding population was subdivided either on the basis of geographic origin and selection goals (multiple-population or MPBS option) or stratified according to genetic value (hierarchical or HOPE option). Most allelic diversity in the natural stands of loblolly pine is present in the domesticated breeding populations. This was true at the aggregate level for both multiple-population (MPBS) and the hierarchical (HOPE) populations. Individual subpopulations within each option had less genetic diversity but it did not decline as generations of improvement increased. Genetic differentiation within the subdivided breeding populations ranged from 1 to 5%, genetic variability is within each subpopulation rather than among subpopulations for both MPBS (〉95%) and the HOPE approaches (〉98%). Nei's Gst estimates for amongpopulation differentiation were biased upwards relative to estimates of θ from Weir and Cockerham (1984).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00222007
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