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  • 1
    Electronic Resource
    Electronic Resource
    Phylogeny of Japanese Papilionid Butterflies Inferred from Nucleotide Sequences of the Mitochondrial ND5 Gene (1999)
    Springer
    Journal of molecular evolution 48 (1999), S. 42-48 
    Details
    ISSN: 1432-1432
    Keywords: Key words: ND5 — mtDNA — Phylogeny — Lepidoptera — Papilionid butterflies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract. Phylogenetic relationships among the Japanese papilionid butterflies were analyzed by comparing 783 nucleotide sequences of the mitochondrial gene encoding NADH dehydrogenase subunit 5 (ND5). Phylogenetic trees of the representative species from each family in the superfamily Papilionoidea revealed that the species of the family Papilionidae and those of all other families formed distinct clusters, with a few species of the family Hesperiidae (Hesperioidea) as an outgroup. In the phylogenetic trees of most Japanese species of the family Papilionidae with Nymphalis xanthomelas (Nymphalidae) as an outgroup, the tribe Parnassiini (Parnassiinae) formed a cluster, and the rest formed the other cluster in which the tribe Zerynthiini (Parnassiinae) and the subfamily Papilioninae formed different subclusters. In the Papilioninae cluster, the tribes Troidini and Graphiini formed a subcluster, and the tribe Papilionini formed the other subcluster. These results generally agree with the traditional classification of the papilionid butterflies based on their morphological characteristics and support the proposed evolutionary genealogy of the butterflies based on their morphology, behavior, and larval host plants, except that the tribes Parnasiini and Zerynthiini (both Parnassiinae) are not in the same cluster.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00006443
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  • 2
    Electronic Resource
    Electronic Resource
    Trans-dominant inhibition of poly(ADP-ribosyl)ation potentiates alkylation-induced shuttle-vector mutagenesis in Chinese hamster cells (1999)
    Springer
    Molecular and cellular biochemistry 193 (1999), S. 31-35 
    Details
    ISSN: 1573-4919
    Keywords: poly(ADP-ribose) polymerase ; mutagenesis ; genomic instability ; alkylating agents ; shuttle vector
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract In most eukaryotic cells, the catalytic activation of poly(ADP-ribose) polymerase (PARP) represents one of the earliest cellular responses to the infliction of DNA damage. To study the biological function(s) of poly(ADP-ribosyl)ation, we have established stable transfectants (COM3 cells) of the SV40-transformed Chinese hamster cell line C060 which conditionally overexpress the PARP DNA-binding domain upon addition of dexamethasone. We could demonstrate that DNA-binding domain overexpression, which leads to trans-dominant inhibition of poly(ADP-ribosyl)ation, potentiates the cytotoxicity of alkylation treatment and of γ-radiation [21]. Likewise, carcinogen-induced gene amplification, viewed as a manifestation of genomic instability, was potentiated by the overexpression of the PARP DNA-binding domain [22]. Recently, we studied the effect of trans-dominant PARP inhibition on mutagenesis by employing a shuttle-vector assay in which mutagen-exposed plasmid pYZ289 is electroporated into COM3 cells. We could show that dexamethasone-induced overexpression of the PARP DNA-binding domain in COM3 cells potentiates the mutagenicity of the alkylating agent N-methyl-N-nitrosourea, while no effect of dexamethasone treatment on mutation frequency was recorded in control cells lacking the PARP DNA-binding domain transgene. Taken together, our results further substantiate the role of poly(ADP-ribosyl)ation in the maintenance of genomic integrity and stability under conditions of genotoxic stress.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006935404987
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  • 3
    Electronic Resource
    Electronic Resource
    Enhanced NOR-1 gene expression by exposure of Chinese hamster cells to high-density 50 Hz magnetic fields (1998)
    Springer
    Molecular and cellular biochemistry 181 (1998), S. 191-195 
    Details
    ISSN: 1573-4919
    Keywords: extremely low frequency magnetic fields ; gene expression ; neuron derived orphan receptor-1 ; signal transduction ; Chinese hamster ovary K1 cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract Enhanced expression of neuron derived orphan receptor (NOR-1) gene was observed by exposure of Chinese hamster ovary K1 (CHO-K1) cells to an extremely low frequency magnetic field (ELFMF) of 50 Hz at 400 mT, but not at 5 mT. The enhanced expression, reaching the maximum at 6 h, was transient and reduced to the control level after exposure to 400 mT ELFMF for 24 h. The NOR-1 expression induced by treatment with forskolin and TPA was further enhanced by the simultaneous treatment with 400 mT ELFMF, in which the maximum response was at 3 h. The NOR-1 expression by these treatments was induced more earlier than that by 400 mT ELFMF alone. When cells were treated with an inhibitor of the protein kinase C (calphostin C or crocetin) and Ca2+ entry blockers (nifedipin and dantrolen) during the 400 mT ELFMF exposure, the enhanced NOR-1 expression was not observed. Exposure of CHO-K1 cells to the high-density 400 mT ELFMF may affect the signal transduction in the cells, resulting in the enhanced NOR-1 gene expression.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006828400868
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  • 4
    Electronic Resource
    Electronic Resource
    Unscheduled DNA synthesis induced by 4-nitroquinoline-1-oxide in xeroderma pigmentosum cells and their complementing heterodikaryons (1980)
    Springer
    Somatic cell and molecular genetics 6 (1980), S. 739-749 
    Details
    ISSN: 1572-9931
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Unscheduled DNA synthesis (UDS) induced by 4-nitroquinoline-1-oxide (4NQO) in the complementation groups A to E and variant xeroderma pigmentosum (XP) cells, and various pairs of complementing XP heterokaryons were investigated. The pattern of UDS induced by various concentrations of 4NQO in normal cells was quite different from those in groups A to D XP cells. The patterns of UDS in group E and variant XP cells were indistinguishable from those of normal cells under our experimental conditions. The levels of UDS induced by 5×10−6 M 4NQO were 13 % of normal in group A, 9% in group B, 17% in group C, 25 % in group D. The heterokaryons obtained by pair-wise fusions between different complementation groups of XP strains showed restored UDS induced by 5×10−6 M 4NQO, while the dikaryons obtained from fusion between the same groups did not.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01538973
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  • 5
    Electronic Resource
    Electronic Resource
    Molecular mechanisms of DNA repair defects and heterogeneity in xeroderma pigmentosum (1977)
    Springer
    Journal of human genetics 22 (1977), S. 129-136 
    Details
    ISSN: 1435-232X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Xeroderma pigmentosum (XP) is an autosomal recessive hereditary disease, first described about 100 years ago. Ultraviolet light in solar spectrum has been believed to cause the skin lesions which often develop into skin cancers. Cleaver's discovery (1968) that the defect in repair of UV damage in DNA is responsible for the disease suggested that there is common DNA repair mechanisms between human being and microorganisms in which the molecular mechanisms of the repair defects have been extensively investigated. This prediction has turned out to be generally true by using the techniques similar to those applied in microorganisms. Fifty XP patients in Japan were examined for their clinical characteristics and the DNA repair of their cells. Results are summarized as follows. (1) More than a half of the patients were children under 13 years of age. (2) Genetic complementation tests were performed on 23 cell strains from the patients; 21 belonging to group A, 1 to D and 1 to E. There was no group C patient which is the most frequent in Europe and U.S.A. (3) Host-cell reactivation of UV-irradiated herpes simplex virus has been shown to be the most reliable method for decisive diagnosis of the XP, reflecting the relative capacities of excision repair. The high frequency of XP patients with low DNA repair capacities, including group A patients, may account for the apparent high frequency of XP patients in Japan. Age distribution of the cancer bearing patients and their DNA repair characteristics suggest that almost all XP patients except for those with nearly normal level of excision repair have developed or will develop skin cancers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01874279
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  • 6
    Electronic Resource
    Electronic Resource
    Symposium: Biotechology in Human Genetics—From Molecules to Whole Body (1984)
    Springer
    Journal of human genetics 29 (1984), S. 167-172 
    Details
    ISSN: 1435-232X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01873539
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