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  • Springer  (3)
  • 1
    Electronic Resource
    Electronic Resource
    Design of new inhibitors specific to the adenosine triphosphate binding site of DNA topoisomerases II (1995)
    Springer
    International journal of peptide research and therapeutics 2 (1995), S. 169-171 
    Details
    ISSN: 1573-3904
    Keywords: UV ; Irradiation ; Crosslinking ; Eukaryotes ; Thermophiles
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary DNA topoisomerases II are involved in the segregation of chromosomes which occurs after DNA replication. These enzymes proceed by nicking and resealing of a phosphodiester bond of the DNA double helix and require the hydrolysis of ATP into ADP and inorganic phosphate. Studies of ATP hydrolysis showed specific properties according to the source of isolation of the enzymes, suggesting the existence of an evolution of the ATP binding site of DNA topoisomerases II. In order to study this evolution, two experimental strategies were followed, first of all an analysis of the topography of the ATP binding site by forming UV crosslinks between ATP and the enzymes, and second the effects of new inhibitors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00119145
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Evolution of the adenosine triphosphate site and design of new inhibitors of DNA topoisomerases II (1997)
    Springer
    International journal of peptide research and therapeutics 4 (1997), S. 403-406 
    Details
    ISSN: 1573-3904
    Keywords: DNA topoisomerases II ; ATP recognition inhibitors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract DNA topoisomerase II is required for chromosome segregation. The enzyme expresses itsbiological activity upon ATP hydrolysis into ADPand inorganic phosphate. Both ATP and dATP areequivalent substrates, but the 8-azidoadenosine5′-triphosphate is a poor substrate comparing toATP for calf thymus DNA topoisomerase II. Thisresult is interesting and can be used for thedesign of new inhibitors or new bettersubstrates and furthermore for biocaptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008885913387
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Evolution of the adenosine triphosphate site and design of new inhibitors of DNA topoisomerases II (1997)
    Springer
    International journal of peptide research and therapeutics 4 (1997), S. 403-406 
    Details
    ISSN: 1573-3904
    Keywords: DNA topoisomerases II ; ATP recognition inhibitors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary DNA topoisomerase II is required for chromosome segregation. The enzyme expresses its biological activity upon ATP hydrolysis into ADP and inorganic phosphate. Both ATP and dATP are equivalent substrates, but the 8-azidoadenosine 5′-triphosphate is a poor substrate comparing to ATP for calf thymus DNA topoisomerase II. This result is interesting and can be used for the design of new inhibitors or new better substrates and furthermore for biocaptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02442907
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    Paper (German National Licenses)
    Fulltext
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