ISSN:
1436-5073
Keywords:
solvent-generated HPLC systems
;
enantiomeric resolution
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract It is shown that enantioselective solvent-generated liquid-liquid and liquid-solid Chromatographic systems with β-cyclodextrin derivatives can be realized. The liquid-liquid systems are based on ternary solvent systems of limited miscibility, containing chiral additives; the chiral stationary phase is spontaneously generated on the porous microparticulate silica used as a solid support. In the solvent-generated adsorption systems a very small proportion of β-cyclodextrin derivatives is added to the mobile phase. These components act as column activators, since they are strongly adsorbed on the RP solid support where they form new stereoselective adsorption sites. It is demonstrated that dynamically generated systems with β-cyclodextrin derivatives as chiral agents are powerful and versatile tools for enantioseparation of different types of compounds. This technique creates not only a new type of selectivity but also leads to very stable and reproducible Chromatographic columns.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01244288
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