ISSN:
1432-1041
Keywords:
xamoterol
;
electrophysiology
;
sino-atrial and atrioventricular conduction
;
coronary artery diseases
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary The electrophysiological effects of xamoterol were studied in ten patients with suspected coronary artery disease by intracardiac electrography. Sino-atrial and atrioventricular conduction times were both slightly shortened by 0.1 mg/kg of xamoterol. The atrioventricular nodal refractory periods were shortened without consistent change in atrial refractoriness. This dose raised mean blood pressure by only 3 mmHg and resting heart rate by only 4 beats/min. The effects suggest a beta1 agonist activity closer to that of prenalterol than that of pindolol under conditions of rest.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00615969
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