Electronic Resource
Springer
Molecular genetics and genomics
122 (1973), S. 149-164
ISSN:
1617-4623
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Summary Yeast mutants resistant to ethidium bromide have been isolated among sensitive grande cells (ϱ+) for their ability to grow on glycerol in the presence of the dye. Mutant cells are also resistant to acriflavin and do not yield petites (ϱ-) when grown on galactose with the mutagen. Genetic analysis reveals that resistance to ethidium bromide is controlled by a cytoplasmic factor, carried by, or linked to, the ϑ determinant (mitochondrial DNA). The expression of resistance to ethidium bromide seems to be related to the presence in the cell of a product of mitochondrial protein synthesis. It is concluded that some mitochondrial DNA sequence is involved in the resistance to ethidium bromide of yeast mitochondria.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00435188
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