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  • gastrointestinal transit  (1)
  • intestinal fluids  (1)
  • Springer  (2)
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  • Springer  (2)
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  • 1
    Electronic Resource
    Electronic Resource
    Dissolution of Hydrocortisone in Human and Simulated Intestinal Fluids (2000)
    Springer
    Pharmaceutical research 17 (2000), S. 183-189 
    Details
    ISSN: 1573-904X
    Keywords: poorly soluble drugs ; hydrocortisone ; dissolution rate ; solubility ; intestinal fluids ; bile salts
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Purpose. To compare solubility and dissolution rate of hydrocortisonein aspirated human intestinal fluids (HIFs) with simulated intestinalfluids (SIFs) and buffer. Methods. Solubility and flux from a rotating disk of hydrocortisonewere measured. The bile salt content, pH and osmotic pressure weredetermined in HIFs. Results. In fasted state the solubility of hydrocortisone was higher inHIFs than in the buffer and SIFs. The flux of hydrocortisone in HIFswas similar to the flux in the buffer but lower than the flux in SIFs atfasted state. Addition of intestinal surfactants in SIFs increasedsolubility and flux at both fasted and fed state. The increase in solubility wascaused by micelle formation in SIFs. The increase in flux may partlybe explained by increased solubility. The bile salt content of the HIFsdid not correlate with the solubility or the flux but pH in the HIFsseems to have some effect on the components of the HIFs resultingin increased solubility. Conclusions. It is possible to perform comparable dissolution tests inHIFs and SIFs. The lack of correlation between the results in HIFs andthe bile salt content may be explained by the relatively low lipofilicity ofthe model drug.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1007517414200
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  • 2
    Electronic Resource
    Electronic Resource
    The effect of density on the gastric emptying of single- and multiple-unit dosage forms (1986)
    Springer
    Pharmaceutical research 3 (1986), S. 208-213 
    Details
    ISSN: 1573-904X
    Keywords: gastrointestinal transit ; pellet density ; floating formulations, gastric emptying
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The gastric emptying of pellets and single units of different densities has been followed in healthy subjects using the technique of gamma scintigraphy. The gastric emptying of the light pellets was affected by their buoyancy in the upper part of the stomach. However, the mean gastric emptying rates of pellets and single units were not significantly affected by density. Floating or buoyant delivery systems may have little advantage over conventional systems. The presence of food in the stomach was found to be the major factor in determining the gastric emptying of single units.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1016334629169
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    Paper (German National Licenses)
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