ISSN:
1432-1041
Keywords:
marijuana
;
delta1-tetrahydrocannabinol
;
plasma elimination half-life
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary The terminal elimination half-life of Δ1-tetrahydrocannabinol (Δ1-THC) was investigated in eight men who were heavy users of marijuana. A stable isotope assay, following smoking deuteriumlabeled Δ1-THC, was used to determine plasma concentrations. In two additional users plasma levels were followed after administration of unlabeled Δ1-THC. The subjects were asked to smoke a “loading dose” of 56 mg Δ1-THC during two days and then abstain from all marijuana use for 4 weeks. The pharmacokinetic behavior was consistent with a multicompartment model with a mean plasma elimination half-life of Δ1-THC of 4.3 days when concentrations were followed for 10–15 days after smoking. In the two subjects with detectable plasma levels during 4 weeks, half-lives of 9.6 and 12.6 days was obtained.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00679783
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