ISSN:
1573-3904
Keywords:
Secondary structure templates
;
Solid-phase synthesis
;
Combinatorial libraries
;
Vaccines
;
Pharmaceuticals
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary Nature has used a ‘library approach’ to constructing ligands for specific receptors and enzymes by combining a limited functional diversity of 20 amino acid side chains with a small array of secondary structure motifs — reverse turns, α-helices and β-strands. The dissection of multidomain proteins into small synthetic conformationally restricted components is an important step in the design of low-molecular-weight nonpeptides that mimic the activity of the native protein. Mimetics of critical functional domains might possess beneficial properties with regard to specificity and therapeutic potential compared to the intact proteinaceous species. Combinatorial secondary-structure-templated libraries provide a powerful engine for the development of novel vaccines and pharmaceuticals.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00131082
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