ISSN:
1573-739X
Keywords:
Acid-base imbalance
;
Buffers
;
Hydrogen
;
Hydrogen carbonate
;
Neutralization
;
Perfusion, rectal
;
Rectum
;
Secretion
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The buffering activity of the human rectum was evaluated in various pilot studies, using a rectal lumen perfusion method. Quantitative alkaline and acid secretion was measured, respectively, by direct titration according to the pH-stat method. The change in composition of the perfusate with regard to the test drug benzoate and the concentration HCO 3 − was detected. The pilot studies suggest that rectal mucosa is capable of neutralizing a pH deviating from the physiological value within a remarkably short time. In the acid region, at least a part of the alkalizing activity is the result of HCO 3 − secretion. It has been shown that this process is stimulated by the H− as well as Cl− ions. In the basic region neutralization very likely occurs by means of H− secretion.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01972908
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