ISSN:
1573-3904
Schlagwort(e):
cis
;
peptide bond conformation
;
1,5-disubstituted tetrazole ring
;
Leu-enkephalin
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Chemie und Pharmazie
Notizen:
Abstract Six analogs of leucine-enkephalin were synthesized in which a 1,5-disubstituted tetrazole ring was incorporated in order to lock selected peptide bonds in cis geometry. The obtained compounds were examined based on their biological effects in vivo and in vitro. Only one analog was completely inactive in binding assays being very weakly active in the antinociceptive test. The remaining five compounds displayed at least weak receptor affinity and in vivo activity.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1023/A:1008895109740
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