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  • International Thermonuclear Experimental Reactor  (1)
  • Key words Hepatocytes  (1)
  • Rat (Wistar)  (1)
  • Springer  (2)
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  • Springer  (2)
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  • 1
    ISSN: 1432-0878
    Keywords: Key words Hepatocytes ; Cell polarity ; Cytoskeleton ; Cytokeratin ; Bile canaliculus ; Rat (Wistar)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract  The usefulness of cultured hepatocytes is limited by the gradual loss of their typical physiological functions that occurs in vitro, mainly due to the absence of microenviromental conditions found in vivo. In this study we describe the effect of retinoic acid on the re-establishment of morphological characteristics and on the reorganization of the cytoskeletal network in cultured rat hepatocytes. Results obtained demonstrate that retinoic acid can influence hepatocyte differentiation, as regards the recovery of cell polarity, polyhedric shape and reformation of bile canaliculi and junctional complexes. The main target of this action appears to be the cytoarchitecture of cytoskeletal components, particularly cytokeratin filaments, which regain the configuration present in intact liver. The reorganization of the intermediate filaments does not seem to be dependent on the induction of higher levels of cytokeratin proteins, but rather appears to be due to post-translational regulation. The effect of retinoic acid on the cytoskeletal organization could determine the stabilization of intercellular contacts by means of junctions, leading to the appearance of morpho-functional characteristics typical of well-differentiated hepatocytes.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1572-9591
    Keywords: Magnetic fusion ; International Thermonuclear Experimental Reactor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract Since 1992, fusion researchers from the U.S., Japan, Europe, Russia, and other countries, have been engaged in a very successful collaboration on the engineering design activities (EDA) of the world's first fusion experimental reactor (ITER). Decisions on whether and where to construct this 1500 MWth, $10 billion facility are scheduled to be made by July 1998. The United States, for budgetary reasons, is faltering in its commitment to fusion development, and thus risks not being involved as a full partner when ITER is built and the long-sought goal of fusion energy is achieved. In this paper, we examine, from the point of view of U.S. industry, the issues and opportunities presented by this historic venture.
    Type of Medium: Electronic Resource
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