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  • 1
    Electronic Resource
    Electronic Resource
    Pharmacological effects of concomitant administration of β-adrenoceptor blocker and agonist in normal subjects: characterization by heart rate response to exercise (1995)
    Springer
    European journal of clinical pharmacology 48 (1995), S. 467-471 
    Details
    ISSN: 1432-1041
    Keywords: Metoprolol ; Denopamine ; exercise ; heart rate response ; healthy volunteers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract The effects of a combination regimen of metoprolol and β1-adrenoceptor agonist denopamine on resting and exercise heart rate have been studied in 10 normal volunteers. Maximal ramp upright bicycle exercise was performed three times at 1-week intervals. Two hours before each exercise test, 5 mg metoprolol plus 20 mg denopamine, 5 mg metoprolol plus a denopamine placebo, or two placebos were orally administered in a double-blind fashion. During exercise after placebo administration, heart rate increased in parallel with the exercise intensity. Compared to the placebo values, resting heart rate was significantly decreased by an average of 10 beats · min−1 by 5 mg metoprolol, whereas it was not altered by the combination regimen. During exercise, however, both the combination regimen and metoprolol alone showed a significant negative chronotropic effect, decreasing peak exercise heart rate by an average of 14 and 21 beats · min−1, respectively. Peak oxygen uptake was also significantly decreased by both regimens. We conclude that concomitant administration of 5 mg metoprolol and 20 mg denopamine exerts an effective β-adrenoceptor blocking action during exercise but a minimal effect at rest in normal subjects. The combination regimen appears to have a favourable pharmacological profile for β-adrenoceptor blocker therapy in patients with chronic heart failure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00194336
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  • 2
    Electronic Resource
    Electronic Resource
    Differential binding of a N-phenylformamidoxime compound in cell-free extracts of benzimidazole-resistant and-sensitive isolates of Venturia nashicola, Botrytis cinerea and Gibberella fujikuroi (1989)
    Springer
    European journal of plant pathology 95 (1989), S. 99-108 
    Details
    ISSN: 1573-8469
    Keywords: benomyl ; Botrytis cinerea ; carbendazim ; fungicide resistance ; Gibberella fujikuroi ; negatively correlated cross-resistance ; thiophanate-methyl ; Venturia nashicola ; DCPF ; N-phenylformamidoximes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Description / Table of Contents: Samenvatting Isolaten vanVenturia nashicola met een hoog niveau van resistentie tegen carbendazim vertoonden ofwel een verhoogde gevoeligheid voor deN-fenylformamidoxim verbinding dichloor-4-propynyloxyfenyl-N-methoxyformamidine (DCPF) of waren evenals matig en zwak carbendazim-resistente isolaten, resistent tegen deze verbinding. Ook carbendazim-resistente isolaten vanBotrytis cinerea bleken gevoelig te zijn geworden voor DCPF. BijGibberella fujikuroi was dit niet het geval. Bindingsactiviteit voor [14C]DCPF in celvrije extracten van het hoog carbendazimresistente en DCPF-resistente isolaat vanV. nashicola bleek hoger te zijn dan bindingsactiviteit in extracten van de DCPF-resistente isolaten die ofwel hoog, matig of zwak-resistent of gevoelig waren voor carbendazim. Bindingsactiviteit voor [14C]carbendazim in extracten van carbendazim-resistente isolaten vanB. cinerea was lager dan die in extracten van gevoelige isolaten en voor [14C]DCPF hoger. In extracten van carbendazim-resistente isolaten vanG. fujikuroi werd ook een lagere [14C]carbendazim bindingsactiviteit gevonden vergeleken met die van gevoelige isolaten; bindingsactiviteit voor [14C]DCPF bleek evenwel onveranderd.
    Notes: Abstract Venturia nashicola isolates with a high level of resistance to carbendazim showed either increased sensitivity or were resistant to theN-phenylformamidoxime compoundN-(3,5-dichloro-4-propynyloyphenyl)-N′-methoxyformamidine (DCPF). Isolates with an intermediate or low level of carbendazim resistance were resistant to DCPF. Increased sensitivity to DCPF was also associated with a high level of carbendazim resistance inBotrytis cinerea but not with a moderate resistance level. Increased sensitivity to DCPF was not observed in carbendazim resistant isolates ofGibberella fujikuroi. Binding of [14C]DCPF in cell-free mycelial extracts of the highly carbendazim-resistant and DCPF-sensitive isolate ofV. nashicola was higher than in those of DCPF-resistant isolates that were either highly-resistant, intermediately resistant, or weakly resistant to carbendazim or were sensitive to carbendazim. [14C]carbendazim binding in extracts of highly carbendazim-resistant isolates ofB. cinerea was lower than that in extracts of sensitive isolates, whereas [14C]DCFP binding was higher. A decreased [14C]carbendazim binding was also observed in extracts of carbendazim-resistant isolates ofG. fujikuroi, binding of [14C]DCPF, however, was similar in extracts of both carbendazim-resistant and sensitive isolates.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01974289
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